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This article has been peer reviewed. It is the authors' final version prior to publication in Clinical Pharmacology and Therapeutics

Volume 103, Issue 1, January 2018, Pages 8-12.

The published version is available at DOI: 10.1002/cpt.929. Copyright © ASCPT


Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients and populations. Accordingly, parity in What vs. How we transform novel mechanistic insights into therapeutic paradigms is essential in achieving success. Aligning molecular discovery with innovations in structures and processes along the discovery-development-regulation-utilization continuum maximizes the return on public and private investments for next-generation solutions in managing health and disease.

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Available for download on Tuesday, January 01, 2019