Document Type
Article
Publication Date
12-30-2024
Abstract
The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDH is often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis. ALDH plays a significant role in various cellular functions, such as metabolism, oxidative stress response, detoxification, and cellular differentiation. Among the ALDH families, ALDH1 has gained considerable attention as a cancer stem cell (CSC) marker due to its significant role in the maintenance of stemness and the differentiation of stem cells (SCs), along with its involvement in tumorigenesis. A description of the cellular mechanisms and physiology of ALDH1 that underlies cancer development is provided. Moreover, current advances in ALDH1-targeting cancer therapies are discussed.
Recommended Citation
Nguyen, Anh L.; Facey, Caroline O. B.; and Boman, Bruce M., "The Significance of Aldehyde Dehydrogenase 1 in Cancers" (2024). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 157.
https://jdc.jefferson.edu/petfp/157
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
39796106
Language
English
Comments
This article is the author's final published version in International Journal of Molecular Sciences, Volume 26, Issue 1, December 2024, Article number 251.
The published version is available at https://doi.org/10.3390/ijms26010251.
Copyright © 2024 by the authors.