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• Control of the mitochondrial ATP production by SR-derived Ca2+ signals includes local, nanodomain Ca2+ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).
• Ca2+ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca2+-activated Ca2+ channel complex.
• The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).
Calcium uptake hotspots in the mitochondria of cardiac muscle at the interface with dyadic SR, Thomas Jefferson University, pathology, cell biology, anatomy
Medical Anatomy | Medical Cell Biology | Medical Pathology
De La Fuente, Sergio; Fernandez-Sanz, Celia; Vail, Caitlin; Agra, Elorm J.; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Finkel, Toren; Murphy, Elizabeth; Joseph, Suresh K.; Sheu, Shey-Shing; and Csordás, György, "Calcium uptake hotspots in the mitochondria of cardiac muscle at the interface with dyadic SR" (2016). Department of Pathology, Anatomy, and Cell Biology Posters. 7.