Of the 167 patients originally included in the study, 43 were either lost to follow up or had insufficient clinical data for comparison. Of the remaining 124 cases, 32 showed loss of stromal Cav-1. Statistical analysis revealed no significant association between stromal Cav-1 loss and the usual markers of disease severity including Gleason grade, stage and presence of metastases. Kaplan-Meier curves showed a significant association between stromal Cav-1 loss and poor disease-free survival and time to recurrence (p<0.05), but no significant association with cancer-specific survival.
Recommended CitationWagner, M.; Dasgupta, A.; Sotgia, F.; West, R. B.; Lisanti, M. P.; and Witkiewicz, A. K., "Loss of Stromal Caveolin-1 Independently Predicts Poor Disease-Free Survival and Time to Recurrence in Patients with Prostate Cancer" (2010). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 49.