Our study suggest that E-cadherin downregulation may lead to EZH20-mediated invasion and metastasis. While strong diffuse EZH2 expression is seen in PDA, overexpression may be present in IPMN.
Recommended CitationToll, A. D.; Dasgupta, A.; Potoczek, M.; Kleer, C. G.; Brody, J. R.; and Witkiewicz, A. K., "Repression of E-Cadherin by the Polycomb Group Protein EZH2 in Pancreatic Cancer" (2009). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 34.