Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.

Authors

Amy H. Lee, University of British Columbia
Casey P. Shannon, PROOF Centre of Excellence
Nelly Amenyogbe, University of British Columbia; Telethon Kids Institute
Tue B. Bennike, Boston Children’s Hospital; Harvard Medical School; Aalborg University
Joann Diray-Arce, Boston Children’s Hospital; Harvard Medical School
Olubukola T. Idoko, London School of Hygiene and Tropical Medicine; Medical Center of the University of Munich
Erin E. Gill, University of British Columbia
Rym Ben-Othman, University of British Columbia
William S. Pomat, Papua New Guinea Institute of Medical Research
Simon D. van Haren, Boston Children’s Hospital; Harvard Medical School
Kim-Anh Lê Cao, The University of Melbourne
Momoudou Cox, London School of Hygiene and Tropical Medicine
Alansana Darboe, London School of Hygiene and Tropical Medicine
Reza Falsafi, University of British Columbia
Davide Ferrari, The University of Melbourne
Daniel J. Harbeson, University of British Columbia
Daniel He, PROOF Centre of Excellence
Cai Bing, University of British Columbia; BCCA
Samuel J. Hinshaw, University of British Columbia
Jorjoh Ndure, London School of Hygiene and Tropical Medicine
Jainaba Njie-Jobe, London School of Hygiene and Tropical Medicine
Matthew A. Pettengill, Thomas Jefferson University; Boston Children's HospitalFollow
Peter C. Richmond, University of Western Australia
Rebecca Ford, Papua New Guinea Institute of Medical Research
Gerard Saleu, Papua New Guinea Institute of Medical Research
Geraldine Masiria, Papua New Guinea Institute of Medical Research
John Paul Matlam, Papua New Guinea Institute of Medical Research
Wendy Kirarock, Papua New Guinea Institute of Medical Research
Elishia Roberts, London School of Hygiene and Tropical Medicine
Mehrnoush Malek, BC Cancer Agency
Guzmán Sanchez-Schmitz, Boston Children’s Hospital; Harvard Medical School
Amrit Singh, PROOF Centre of Excellence; University of British Columbia
Asimenia Angelidou, Boston Children’s Hospital
Kinga K. Smolen, Boston Children’s Hospital; Harvard Medical School
Diana Vo, Boston Children’s Hospital
Ken Kraft, Boston Children’s Hospital; Harvard Medical School
Kerry McEnaney, Boston Children’s Hospital; University of British Columbia
Sofia Vignolo, Boston Children’s Hospital
Arnaud Marchant, Université libre de Bruxelles
Ryan R. Brinkman, BC Cancer Agency; University of British Columbia
Al Ozonoff, Boston Children’s Hospital; Harvard Medical School
Robert E.W. Hancock, University of British Columbia
Anita H.J. van den Biggelaar, University of Western Australia
Hanno Steen, Boston Children’s Hospital; London School of Hygiene and Tropical Medicine
Scott J. Tebbutt, PROOF Centre of Excellence; University of British Columbia; UBC Centre for Heart and Lung Innovation
Beate Kampmann, London School of Hygiene and Tropical Medicine; London School of Hygiene and Tropical Medicine
Ofer Levy, Boston Children’s Hospital; Harvard Medical School; Broad Institute
Tobias R. Kollmann, University of British Columbia; Telethon Kids Institute

Document Type

Article

Publication Date

3-12-2019

Comments

This article has been peer reviewed. It is the author’s final published version in Nature Communications, Volume 10, Issue 1, March 2019, Article number 1092.

The published version is available at https://doi.org/10.1038/s41467-019-08794-x. Copyright © Lee et al.

Abstract

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data fromblood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.

Recommended Citation

Lee, Amy H.; Shannon, Casey P.; Amenyogbe, Nelly; Bennike, Tue B.; Diray-Arce, Joann; Idoko, Olubukola T.; Gill, Erin E.; Ben-Othman, Rym; Pomat, William S.; van Haren, Simon D.; Cao, Kim-Anh Lê; Cox, Momoudou; Darboe, Alansana; Falsafi, Reza; Ferrari, Davide; Harbeson, Daniel J.; He, Daniel; Bing, Cai; Hinshaw, Samuel J.; Ndure, Jorjoh; Njie-Jobe, Jainaba; Pettengill, Matthew A.; Richmond, Peter C.; Ford, Rebecca; Saleu, Gerard; Masiria, Geraldine; Matlam, John Paul; Kirarock, Wendy; Roberts, Elishia; Malek, Mehrnoush; Sanchez-Schmitz, Guzmán; Singh, Amrit; Angelidou, Asimenia; Smolen, Kinga K.; Vo, Diana; Kraft, Ken; McEnaney, Kerry; Vignolo, Sofia; Marchant, Arnaud; Brinkman, Ryan R.; Ozonoff, Al; Hancock, Robert E.W.; van den Biggelaar, Anita H.J.; Steen, Hanno; Tebbutt, Scott J.; Kampmann, Beate; Levy, Ofer; and Kollmann, Tobias R., "Dynamic molecular changes during the first week of human life follow a robust developmental trajectory." (2019). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 270.
https://jdc.jefferson.edu/pacbfp/270

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

30862783

Language

English