Intracellular Ca 2+ sensing: role in calcium homeostasis and signaling

Authors

Rafaela Bagur, Thomas Jefferson UniversityFollow
György Hajnóczky, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

6-15-2017

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Molecular Cell, Volume 66, Issue 6, June 2017, Pages 780-788.

The published version is available at https://doi.org/10.1016/j.molcel.2017.05.028. Copyright © Elsevier

Abstract

Ca²⁺ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific targets depends on spatiotemporal patterning of the calcium signal and decoding it by multiple, tunable, and often strategically positioned Ca²⁺-sensing elements. Ca²⁺ is detected by specialized motifs on proteins that have been biochemically characterized decades ago. However, the field of Ca²⁺ sensing has been reenergized by recent progress in fluorescent technology, genetics, and cryo-EM. These approaches exposed local Ca²⁺-sensing mechanisms inside organelles and at the organellar interfaces, revealed how Ca²⁺ binding might work to open some channels, and identified human mutations and disorders linked to a variety of Ca²⁺-sensing proteins. Here we attempt to place these new developments in the context of intracellular calcium homeostasis and signaling. © 2017 Elsevier

Recommended Citation

Bagur, Rafaela and Hajnóczky, György, "Intracellular Ca 2+ sensing: role in calcium homeostasis and signaling" (2017). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 244.
https://jdc.jefferson.edu/pacbfp/244

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

28622523

Language

English