1) Control of the mitochondrial ATP production by SR-derived Ca2+ signals includes local, nanodomain Ca2+ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).
2) Ca2+ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca2+-activated Ca2+ channel complex.
3) The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).
Recommended CitationDe La Fuente, Sergio; Vail, Caitlin; Agra, Elorm J.; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Finkel, Toren; Murphy, Elizabeth; Sheu, Shey-Shing; and Csordás, György, "Strategic distribution of the mitochondrial Ca2+ uniporter in cardiac mitochondria" (2015). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 167.