Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology.

Authors

J. Melrose, University of Sydney; The University of New South Wales
S. Tessier, Thomas Jefferson University; Temple UniversityFollow
M. V. Risbud, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

1-12-2021

Comments

This article is the authors’ final published version in European Cells and Materials, Volume 41, January 2021, Pages 52-72.

The published version is available at https://doi.org/10.22203/eCM.v041a05. Copyright © Melrose et al.

Abstract

Disc degeneration and associated back and neck pain elicits a substantial burden on healthcare systems and the individuals affected, necessitating the development of novel therapeutic strategies. This goal can only be achieved by a better understanding of intervertebral disc development, homeostasis and pathogenesis. A number of genetic and in-bred murine models are reviewed to underscore the importance of the mouse as an animal model of choice for the assessment of intervertebral disc pathobiology. Appraisals of the differences between mouse and human musculoskeletal systems and proteoglycan structures are also included. A number of important target pathways and molecules have been identified, many of which are worthy of further examination, requiring that the activity of these be confirmed in large animal models and assessed in the context of therapeutic intervention.

Recommended Citation

Melrose, J.; Tessier, S.; and Risbud, M. V., "Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology." (2021). Department of Orthopaedic Surgery Faculty Papers. Paper 151.
https://jdc.jefferson.edu/orthofp/151

Creative Commons License

This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License.

PubMed ID

33432564

Language

English