Document Type
Article
Publication Date
5-1-2024
Abstract
PURPOSE: To investigate whether leukocytospermia (defined as the presence of ≥ 1 × 10
METHODS: This was a retrospective cohort study including 5425 cycles between January 2012 to December 2021 at a single large university-affiliated fertility clinic. The primary outcome was live birth rate (LBR).
RESULTS: The prevalence of leukocytospermia was 33.9% (n = 1843). Baseline characteristics including female age, BMI, AMH, Day 3 FSH, and male partner's age were similar in cycles with and without leukocytospermia. The LBR after the first euploid embryo transfer was similar in those with and without leukocytospermia (62.3% vs. 63% p = 0.625). Secondary outcomes including clinical pregnancy rate (CPR), sustained implantation rate (SIR), fertilization (2PN) rate, blastulation rate, and aneuploidy rate were also evaluated. The CPR (73.3% vs 74.9%, p = 0.213) and SIR (64.6% vs. 66%, p = 0.305) were similar in both groups. The 2PN rate was also similar in both groups (85.7% vs. 85.8%, p = 0.791), as was the blastulation rate per 2PN (56.7% vs. 57.5%, p = 0.116). The aneuploidy rate was not significantly different between groups (25.7% vs 24.4%, p = 0.053). A generalized estimation equation with logistic regression demonstrated that the presence leukocytospermia did not influence the LBR (adjusted OR 0.878; 95% CI, 0.680-1.138).
CONCLUSION: Leukocytospermia diagnosed just prior to an IVF cycle with PGT-A does not negatively impact clinical or embryologic outcomes.
Recommended Citation
Gill, Pavan; Puchalt, Nicolas Garrido; Molinaro, Thomas; Werner, Marie; Seli, Emre; Hotaling, James; and Cheng, Philip, "Leukocytospermia does not Negatively Impact Outcomes in In Vitro Fertilization Cycles with Intracytoplasmic Sperm Injection and Preimplantation Genetic testing For Aneuploidy: Findings from 5435 Cycles" (2024). Jefferson Health - New Jersey Papers. Paper 4.
https://jdc.jefferson.edu/newjerseyfp/4
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author’s final published version in Journal of Assisted Reproduction and Genetics, Volume 41, 2024, Pages 1213-1219.
The published version is available at https://doi.org/10.1007/s10815-024-03085-x. Copyright © The Author(s) 2024.
Publication made possible in part by support through a transformative agreement between Thomas Jefferson University and the publisher.