Document Type
Article
Publication Date
6-3-2025
Abstract
OBJECTIVES: The performance of the Pipeline Embolization Device (PED) and relatively newer double-layered Flow Re-Direction Endoluminal Device (FRED) have been studied for the treatment of intracranial aneurysms, but direct comparisons between PED and FRED are limited. The current systematic review aims at comparing the efficacy and safety of PED and FRED.
METHODS: A systematic review of the literature was conducted according to the PRISMA guideline. PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched, and related records were identified. A meta-analysis of double-arm studies comparing PED and FRED was conducted on angiographic and clinical outcomes, retreatment rates, and complications following treatment.
RESULTS: A total of 15 retrospective double-arm studies, published from 2017 to 2023, were included. Studies were predominantly from the US and Germany. A total of 2231 patients across these studies were analyzed, with 1214 treated using PED and 1017 with FRED. Angiographic outcomes demonstrated no significant difference in occlusion rates between PED and FRED (P = 0.35). Retreatment rates trended lower with FRED (P = 0.08) but were not significant. Moreover, adjunctive coiling was more frequently utilized with FRED (P = 0.04). Complication rates were similar between the two groups. There was no significant difference in mortality between the two devices (P = 0.80).
CONCLUSION: This review provides evidence on the comparable safety and effectiveness of FRED with PED. PED and FRED show comparable angiographic outcomes, with a trend toward lower retreatment rates with FRED. Complication rates and mortality are comparable, with slightly higher historical hemorrhage rate for PED.
Recommended Citation
Maroufi, Seyed; Fallahi, Mohammad; Waqas, Muhammad; Bin-Alamer, Othman; Koneru, Manisha; Roy, Joanna; Khalife, Jane; Shaikh, Hamza; and Tonetti, Daniel, "Comparison Between Pipeline Embolization Device (PED) Versus Flow Redirection Endoluminal Device (FRED) for Intracranial Aneurysms: A Comprehensive Systematic Review and Meta-Analysis" (2025). Department of Neurosurgery Faculty Papers. Paper 266.
https://jdc.jefferson.edu/neurosurgeryfp/266
Creative Commons License
This work is licensed under a
Creative Commons Public Domain Dedication 1.0 License.
PubMed ID
40456928
Language
English
Included in
Diagnosis Commons, Equipment and Supplies Commons, Health Services Administration Commons, Neurosurgery Commons, Surgical Procedures, Operative Commons, Therapeutics Commons
Comments
This article is the author's final published version in Neurosurgical review, Volume 48, Issue 1, 2025, Article number 475.
The published version is available at https://doi.org/10.1007/s10143-025-03595-x.
This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2025