Document Type
Article
Publication Date
12-1-2018
Abstract
Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50-200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.
Recommended Citation
Solomon, E. A.; Kragel, J. E.; Gross, R.; Lega, B.; Sperling, M. R.; Worrell, G.; Sheth, S. A.; Zaghloul, K. A.; Jobst, B. C.; Stein, J. M.; Das, S.; Gorniak, R.; Inman, C. S.; Seger, S.; Rizzuto, D. S.; and Kahana, M. J., "Medial temporal lobe functional connectivity predicts stimulation-induced theta power." (2018). Department of Neurology Faculty Papers. Paper 171.
https://jdc.jefferson.edu/neurologyfp/171
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
30361627
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Nature Communications, Volume 9, Issue 1, December 2018, Article number 4437.
The published version is available at https://doi.org/10.1038/s41467-018-06876-w. Copyright © Solomon et al.