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  • Acne is a common skin condition when the pores are clogged by particles like dead skin or oil, affecting approximately 50 million individuals in the U.S.1
  • Over a third of females experience moderate-severe forms that persist into adulthood and that number seems to be on the rise3
  • Persistent moderate-severe acne often requires systemic medications and oral antibiotics are the most frequently prescribed therapy2
  • Dermatologists prescribe more antibiotics per provider than any other specialty, and often for longer durations than recommended2
  • The inappropriate use of oral antibiotics is contributing to bacterial resistance and disruption of the microbiome2
  • Spironolactone is an androgen receptor antagonist that has been used off-label for acne treatment for over 30 years3
  • A 2009 Cochrane review found that randomized trials evaluating spironolactone as a treatment for acne were too limited and small to support its clinical effectiveness1
  • There have since been multiple large studies supporting its utility1

Publication Date



acne, post-adolescent, adult females, spironolactone, oral antibiotics


Dermatology | Medicine and Health Sciences


Capstone presentations were completed in partial fulfillment of the Master of Science degree in Physician Assistant Studies at Thomas Jefferson University.

Document Type


The Safety and Efficacy of Spironolactone versus Oral Antibiotics for Moderate-severe Acne in Post-adolescent Females

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Dermatology Commons