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Depression affects millions globally - Treatment-resistant depression (TRD) is defined as failure to respond to two antidepressant trials of adequate dose and duration
Traditional Treatment for TRD:
Switching or adding medications atypical antipsychotics - Limitations include delayed action, side effects, and limited efficacy
Alternative Treatment Options:
- A dissociative anesthetic with potential antidepressant effects
- Targets the NMDA receptor and activates AMPA receptor.
- Shows rapid and potent antidepressant effects; however, not FDA-approved for depression
- Monoamine Oxidase Inhibitors (MAOIs):
- Antidepressants used since the 1950s
- Inhibits the enzyme metabolizing neurotransmitters.
- Limitations: Dietary restrictions and drug interactions and longstanding safety concerns
Importance of Comparison:
Given limitations of traditional treatments and promising results from Ketamine and MAOIs, there's a need to compare their safety and efficacy. This will provide clinicians with informed choices for their patients.
To compare the safety and efficacy of ketamine and MAOIs for TRD to guide clinical decisions and future research.
MAOIs, ketamine, TRD
Medicine and Health Sciences | Psychiatric and Mental Health
Guinan, Riley, "Safety and Efficacy of Adjunctive Esketamine vs. MAOIs in TRD in Adults" (2023). Master of Science in Physician Assistant Studies Capstone Presentations (Center City). 15.