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Cardiovascular disease is the leading cause of death for men and women in the United States.7­­

There are four main types of CVD:

  1. Coronary heart disease
  2. Strokes & TIAs
  3. Peripheral arterial disease
  4. Aortic disease

Coronary artery disease (CAD) is the most prevalent and most common cause of atherosclerosis

Antiplatelet medications remain the cornerstone of medical therapy for primary and secondary atherosclerotic CAD prevention.

Aspirin is prescribed for:

  • Individuals with a history of MI or ischemic stroke to prevent a recurrence.
  • When a myocardial infarction (MI) is suspected to avoid further infarction.
  • Thromboembolism prevention after hip surgeries, transient ischemic attack (TIA) prevention, or adults at a higher risk for atherosclerotic CVD.

Clopidogrel is prescribed for:

  • Individuals with a history of of MIs, ischemic strokes, and peripheral artery disease.
  • Use during a percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable ischemic heart disease.
  • Symptomatic carotid artery stenosis
  • Secondary prevention post-coronary artery bypass grafting
  • Peripheral artery percutaneous angioplasty in peripheral artery bypass grafting

Publication Date



CVD, aspirin, clopidogrel, bleeding, antiplatelet


Medicine and Health Sciences | Pulmonology


Capstone presentations were completed in partial fulfillment of the Master of Science degree in Physician Assistant Studies at Thomas Jefferson University.

Document Type


A Comparison of Bleeding Risk in Patients with Cardiovascular Disease Treated with Aspirin versus Clopidogrel

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Pulmonology Commons