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Adverse Childhood Events (ACEs) and trauma are established determinants of poor health later in life. As a factor often overlooked in the clinical setting, the provision of inappropriate care of vulnerable patients represents a serious concern. Among the population of high-utilizers, that place a disproportionate burden on the healthcare system, recognition of these factors is also essential in providing optimal care. Trauma-informed care has become increasingly recognized as a compassionate model to treat high-need, high-utilizing patients. A rapid review was conducted in order to evaluate the value of trauma-informed care in addressing the needs of super-utilizers with a history of trauma. This review analyzed 11 articles representing patient perspectives, provider perspectives, and evaluation of trauma-informed interventions. Findings suggests that (1) providers lack to capability and confidence to treat traumatized patients, (2) lack of compassion and insensitivity lead to negative health experiences for patients, and (3) integration of education and training reflect positive ways to improve patient experiences and outcomes. Consequently, it is recommended that early and ongoing education as well as training for providers to practice in a trauma-informed manner be provided.