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Colorectal cancer (CRC) screening is an effective measure in reducing cancer mortality and providing better CRC outcome, yet it is underutilized, especially amongst underserved populations. In Penn’s Community Service Area (CSA), 1 in 4 adults aged 50 years and older are non-compliant with screening. This study aims to determine response rates of colonoscopy screening with mailed fecal immunochemical (FIT) test kits for patients residing in Penn’s community service area to patients residing outside the community service area based on area-level socioeconomic variables. Furthermore, a proximity analysis, via buffers, was conducted to explore the impact of proximity of a patient’s residence to Hospital of the University of Pennsylvania (HUP) and response rate of patients residing within Penn’s CSA. Patients were selected from Penn’s IRB-approved Colorectal Cancer Screening Outreach (CRCSO) pilot program. Eligibility for this study was based on age (between 50-75yrs), residence in the Philadelphia-Camden-Wilmington Metropolitan Area (MSA), screening status and documentation of at least 2 clinic visits at a primary family medicine clinic within two years prior to the review of patient medical records. A total of 897 patients were mailed FIT kits: 56.3% were women, 43.7% men, 68.9% Black/African-American, 20.5% white, 5.2% Asian, and 5.4% other/unknown race. Response rate, overall, was 29% (n=896). There was a positive association between response rate and race, as well as response rate and census tract (CT)-level median household income. We found that Black/African American participants had significantly higher response rates in both service areas (63.1%, overall), compared to all racial groups included in this analysis. Results will be shared with the CRCSO program to provide insight on the impact of the pilot program within their Community Service Area.