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It has previously been suggested that the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) has prognostic significance. Furthermore, gene expression profiling in DLBCL patients has identified separate subsets with glycolytic and mitochondrial (oxidative phosphorylative) metabolic signatures.
Glycolytic metabolism forms the basis for FDG PET scans, widely used in staging and response assessment in DLBCL. While many assume that the tumor as a whole is primarily glycolytic, the metabolic patterns of cancer cells (C) and surrounding cancer-associated stromal cells (CAS) remain relatively unknown. We investigated the in situ metabolic patterns of C and CAS cells as well as tumor-associated macrophages (TAM) in DLBCL.
Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma, Tumor–Stromal Metabolic Coupling
Gooptu, MD, Mahasweta; Dulau Florea, MD, Alina E.; Leiby, PhD, Benjamin E.; Pro, MD, Barbara; Sprandio, Jr. MD, John David; Whitaker-Menezes, PhD, Diana; Cotzia, MD, Paolo; Uppal, MD, Guldeep; Caro, MD, Jaime; Gong, MD, Jerald Z.; and Martinez-Outshoorn, MD, Ubaldo E., "Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling" (2015). Department of Medical Oncology Posters. 2.