BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved.
METHODS: The level of cytosolic Ca
RESULTS: Here, we demonstrated that TNFα induced extracellular Ca
CONCLUSIONS: Our study provides the evidence supporting a novel mechanism by which TNFα induces extracellular Ca
Recommended CitationZhu, Jianjun; Jin, Mingpeng; Wang, Jiaojiao; Zhang, Hui; Wu, Yousheng; Li, Deyang; Ji, Xiaoying; Yang, Hushan; Yin, Chun; Ren, Tingting; and Xing, Jinliang, "TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells" (2018). Department of Medical Oncology Faculty Papers. Paper 76.
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