Nonalcoholic Fatty Liver Disease (NAFLD) is a growing global phenomenon, and its damaging effects in terms of cardiovascular disease (CVD) risk are becoming more apparent. NAFLD is estimated to affect around one quarter of the world population and is often comorbid with other metabolic disorders including diabetes mellitus, hypertension, coronary artery disease, and metabolic syndrome. In this review, we examine the current evidence describing the many ways that NAFLD itself increases CVD risk. We also discuss the emerging and complex biochemical relationship between NAFLD and its common comorbid conditions, and how they coalesce to increase CVD risk. With NAFLD's rising prevalence and deleterious effects on the cardiovascular system, a complete understanding of the disease must be undertaken, as well as effective strategies to prevent and treat its common comorbid conditions.
Josloff, Kevan; Beiriger, Jacob; Khan, Adnan; Gawel, Richard J.; Kirby, Richard S.; Kendrick, Aaron; Rao, Abhinav K.; Wang, Roy; Schafer, Michelle; Pearce, Margaret; Chauhan, Kashyap; Shah, Yash B.; Marhefka, Gregary D.; and Halegoua-De Marzio, Dina, "Comprehensive Review of Cardiovascular Disease Risk in Nonalcoholic Fatty Liver Disease" (2022). Department of Medicine Faculty Papers. Paper 399.
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