Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair factors (DDRF) play a vital role in maintaining genomic integrity. However, how DDCFs and DDRFs are modulated under physiological and pathological conditions are not fully known. We took an experimental database analysis to determine the expression of 26 DNA DD
Recommended CitationZeng, Huihong; Nanayakkara, Gayani K; Shao, Ying; Fu, Hangfei; Sun, Yu; Cueto, Ramon; Yang, William Y; Yang, Qian; Sheng, Haitao; Wu, Na; Wang, Luqiao; Yang, Wuping; Chen, Hongping; Shao, Lijian; Sun, Jianxin; Qin, Xuebin; Park, Joon Y.; Drosatos, Konstantinos; Choi, Eric T.; Zhu, Qingxian; Wang, Hong; and Yang, Xiaofeng, "DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks." (2018). Department of Medicine Faculty Papers. Paper 238.
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