Drug-induced orthostatic hypotension (OH) is a common side effect of heterocyclic and MAOI antidepressant medications. It usually does not respond to conservative treatment and drug treatments with mineralocorticoids or central dopaminergic antagonists such as metoclopramide have significant long-term side effects that limit their use. Domperidone, a peripherally acting dopaminergic antagonist with few side effects, has been used in a number of small clinical trials to treat OH of various etiologies. We reviewed 9 studies of domperidone in the treatment of OH. Although limited by small sample sizes and poor design, these studies generally showed successful treatment of OH by domperidone. Further controlled studies of domperidone for antidepressant induced OH in relevant patient samples are warranted.
McDonald, M.D., Daniel E. and Lam, M.D., F.R.C.P.(C), Raymond W.
"Domperidone for Drug-Induced Orthostatic Hypotension-A Review,"
Jefferson Journal of Psychiatry: Vol. 10
, Article 5.
Available at: https://jdc.jefferson.edu/jeffjpsychiatry/vol10/iss1/5