Document Type
Article
Publication Date
3-7-2025
Abstract
Fluorescence lifetime imaging ophthalmoscopy (FLIO) has emerged as an innovative advancement in retinal imaging, with the potential to provide in vivo non-invasive insights into the mitochondrial metabolism of the retina. Traditional retinal imaging, such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) intensity imaging, focus solely on structural changes to the retina. In contrast, FLIO provides data that may reflect retinal fluorophore activity, some of which may indicate mitochondrial metabolism. This review builds upon the existing literature to describe the principles of FLIO and established uses in retinal diseases while introducing the potential for FLIO in neurodegenerative conditions.
Recommended Citation
Markowitz, Daniel M.; Affel, Elizabeth; Hajnóczky, György; and Sergott, Robert C., "Future Applications of Fluorescence Lifetime Imaging Ophthalmoscopy in Neuro-Ophthalmology, Neurology, and Neurodegenerative Conditions" (2025). Farber Institute for Neuroscience Faculty Papers. Paper 67.
https://jdc.jefferson.edu/farberneursofp/67
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
40125394
Language
English
Included in
Diagnosis Commons, Eye Diseases Commons, Nervous System Diseases Commons, Neurology Commons
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Neurology, Volume 16, 2025, Article number 1493876.
The published version is available at https://doi.org/10.3389/fneur.2025.1493876.
Copyright © 2025 Markowitz, Affel, Hajnóczky and Sergott