Liver ischemia-reperfusion (I/R) injury occurs during transplantation and major hepatic surgery, which may lead to postoperative liver dysfunction. More and more traditional Chinese medicines (TCMs) have been used to treat liver ischemia-reperfusion injury. The purpose of this review is to evaluate the different protective effects of TCMs in the treatment of liver ischemia-reperfusion injury and to summarize its possible mechanisms. The results indicate that TCMs attenuate liver I/R injury via multiple mechanisms, including antioxidation stress, anti-inflammatory response, antiapoptosis, and inhibiting endoplasmic reticulum stress. However, the in-depth mechanism of the protective effects of these traditional Chinese medicines still remains unknown.
Ma, Wen; Tang, Songling; Xie, Dina; Gu, Guoqiang; and Gan, Lu, "The Protective Effect of Traditional Chinese Medicine on Liver Ischemia-Reperfusion Injury." (2021). Department of Emergency Medicine Faculty Papers. Paper 136.
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