OBJECTIVE: Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection.
METHODS AND RESULTS: Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P
CONCLUSIONS: Taken together, these results demonstrated for the first time that Cav-3 plays an essential role in APN transmembrane signaling and APN anti-ischemic/cardioprotective actions.
Recommended CitationWang, Yajing; Wang, Xiaoliang; Jasmin, Jean-François; Lau, Wayne Bond; Li, Rong; Yuan, Yuexin; Yi, Wei; Chuprun, Kurt; Lisanti, Michael P.; Koch, Walter J; Gao, Erhe; and Ma, Xin-Liang, "Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection." (2012). Department of Emergency Medicine Faculty Papers. Paper 12.