Document Type
Article
Publication Date
4-23-2025
Abstract
Post-infection sequela of several viruses have been linked with Parkinson's disease (PD). Here, we investigated whether mice infected with SARS-CoV-2 alone or in combination with two putative Parkinsonian toxins, MPTP and paraquat, increased the susceptibility to develop Parkinsonian pathology. We also examined if G2019S LRRK2 mice had any change in sensitivity to SARS-CoV-2 as well as if vaccination against this virus altered any neuropathology. Infection with WA-1/2020 or Omicron B1.1.529 strains sensitized both WT and G2019S LRRK2 mice to the neuropathological effects of a subtoxic exposure to MPTP, but not paraquat. These neuropathologies were rescued in WT mice vaccinated with mRNA- or protein-based SARS-CoV-2 vaccines. However, G2019S LRRK2 mutant mice were only protected with the protein-based vaccine. These results highlight the role of both environmental exposures and familial background on the development of Parkinsonian pathology secondary to viral infection and the benefit of vaccines in reducing these risks.
Recommended Citation
Chatterjee, Debotri; Kurup, Drishya; and Smeyne, Richard Jay, "Environmental Exposures and Familial Background Alter the Induction of Neuropathology and Inflammation After SARS-CoV-2 Infection" (2025). Department of Neuroscience Faculty Papers. Paper 88.
https://jdc.jefferson.edu/department_neuroscience/88
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Comments
This article is the author’s final published version in npj Parkinson's Disease, Volume 11, 2025, Article number 86.
The published version is available at https://doi.org/10.1038/s41531-025-00925-0. Copyright © The Author(s) 2025.