Barrier-repair prescription moisturizers: Do we really need them? Facts and controversies.

Authors

Ronni Wolf, The Dermatology Unit, Kaplan Medical Center, Rechovot, Israel. Affiliated to The School of Medicine, Hebrew University and Hadassah Medical Center, Jerusalem, Israel.
Lawrence Parish, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

11-1-2013

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Clinics in Dermatology.

Volume 31, Issue 6, November-December 2013, Pages 787-91.

The published version is available at DOI: 10.1016/j.clin dermatol.2013.05.018. Copyright © Elsevier Inc.

Abstract

There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.

Recommended Citation

Wolf, Ronni and Parish, Lawrence, "Barrier-repair prescription moisturizers: Do we really need them? Facts and controversies." (2013). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 31.
https://jdc.jefferson.edu/dcbfp/31

PubMed ID

24160288