There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.
Recommended CitationWolf, Ronni and Parish, Lawrence, "Barrier-repair prescription moisturizers: Do we really need them? Facts and controversies." (2013). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 31.