Document Type
Report
Publication Date
11-1-2024
Abstract
A 68-year-old woman with a history of seizures on cenobamate presented with an itchy rash all over her body. The rash started about one month prior to her presentation to the dermatology clinic. The rash was initially treated with topical triamcinolone with improvement at one-month follow-up. However, four months later the rash flared and there was concern that cenobamate was the cause. Biopsy was performed showing vacuolar interface dermatitis with atrophy, suggestive of subacute lupus erythematosus. Blood work revealed positive antinuclear antibody, anti-ribonucleoprotein antibody, Sjogren Anti-SS-A and positive histone antibody. Given the worsening rash, positive labs, and cenobamate as the only changed drug several months before initial onset, she was diagnosed with drug-induced subacute cutaneous lupus erythematous and her cenobamate was discontinued. To the best of your knowledge, this is the first reported case of a medication in the carbamate family leading to drug induced subacute cutaneous lupus erythematosus.
Recommended Citation
Bhatti, Safiyyah; Joffe, Daniel; Webster, Timothy; Lee, Jason; and Nikbakht, Neda, "Drug-Induced Subacute Cutaneous Lupus Erythematous From Cenobamate: Case Presentation and Review of the Literature" (2024). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 200.
https://jdc.jefferson.edu/dcbfp/200
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Included in
Chemicals and Drugs Commons, Dermatology Commons, Skin and Connective Tissue Diseases Commons
Comments
This article is the author's final published version in Dermatology Online Journal, Volume 30, Issue 6, November 2024.
The published version is available at https://doi.org/10.5070/D330664689.
Copyright © 2024 by the author(s).