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Manuscripts from 2019

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Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth., Rachel M. DeRita, Aejaz Sayeed, Vaughn Garcia, Shiv Ram Krishn, Christopher D. Shields, Srawasti Sarker, Andrea Friedman, Peter McCue, Sudheer Kumar Molugu, Ulrich Rodeck, Adam P. Dicker, and Lucia R. Languino

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CADM1 is a TWIST1-regulated suppressor of invasion and survival., Edward J. Hartsough, Michele B. Weiss, Shea A. Heilman, Timothy J. Purwin, Curtis H Kugel, Sheera R. Rosenbaum, Dan A. Erkes, Manoela Tiago, Kim Hookim, Inna Chervoneva, and Andrew E. Aplin

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Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment., Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, and Karen M. Bussard

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Cyclin D1 integrates G9a-mediated histone methylation., Zhiping Li, Xuanmao Jiao, Gabriele Di Sante, Adam Ertel, Mathew C. Casimiro, Min Wang, Sanjay Katiyar, Xiaoming Ju, D. V. Klopfenstein, Aydin Tozeren, William Dampier, Iouri Chepelev, Albert Jeltsch, and Richard G. Pestell

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Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells., Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, and Bruno Calabretta

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Clotilde Théry; Kenneth W. Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D. Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K. Atkiin-Smith; D. Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N. Bauer; Amy A. Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C. Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E. Borràs; Steffi Bosch; Chantal M. Boulanger; Xandra Breakefield; Andrew M. Breglio; Meadhbh Á. Brennan; David R. Brigstock; Alain Brisson; Marike L.D. Broekman; Jacqueline F. Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H. Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I. Buzás; James Bryan Byrd; Giovanni Camussi; David R.F. Carter; Sarah Caruso; Lawrence W. Chamley; Yu-Ting Chang; Chichen Chen; Shuai Chen; Lesley Cheng; Andrew R. Chin; Aled Clayton; Stefano P. Clerici; Alex Cocks; Emanuele Cocucci; Robert J. Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank A.W. Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D’ Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F. De Santana Junior; Olivier De Wever; Hernando A. del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C. Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R. Dourado; Tom A.P Driedonks; Filipe V. Duarte; Heather M. Duncan; Ramon M. Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M. Falcón-Pérez; Farah Fatima; Jason E. Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah C.I. Goberdhan; André Görgens; Sharon M. Gorski; David W. Greening; Julia Christina Gross; Alice Gualerzi; Gopal N. Gupta; Dakota Gustafson; Aase Handberg; Reka A. Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F. Hill; Fred H. Hochberg; Karl F. Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M. Inal; Mustafa Isin; Alena Ivanova; Hannah K. Jackson; Soren Jacobsen; Steven M. Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M. Johnson; Jennifer C. Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T. Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J. Klinke II; Miroslaw Kornek; Maja M. Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V. Kurochkin; Gina D. Kusuma; Sören Kuypers; Saara Laitinen; Scott M. Langevin; Lucia R. Languino; Joanne Lannigan; Cecilia Lässer; Louise C. Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S. Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac T.S. Li; Ke Liao; Sten F. Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A. Lombard; Magdalena J. Lorenowicz; Ákos M. Lörincz; Jan Lötvall; Jason Lovett; Michelle C. Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R. Lunavat; Sybren L.N. Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S. Martens-Uzunova; Lorena Martin-Jaular; M. Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K. McGinnis; Mark J. McVey; David G. Meckes, Jr.; Katie L. Meehan; Inge Mertens; Valentina R. Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C. Muth; Kathryn H. Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P. Nolan; Esther N.M. Nolte-’ t Hoen; Nicole Noren Hooten; Lorraine O’Driscoll; Tina O’Grady; Ana O’Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A. Ortiz; Xabier Osteikoetxea; Ole Ostegaard; Matias Ostrowski; Jaesung Park; D. Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W. Pfaffl; Donald G. Phinney; Bartijn C.H. Pieters; Ryan C. Pink; David S. Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan K.H. Poon; Bonita H. Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L. Raffai; Stefania Raimondo; Janusz Rak; Marcel I. Ramirez; Graça Raposo; Morsi S. Rayyan; Neta Regev-Rudzki; Fran L. Ricklefs; Paul D. Robbins; David D. Roberts; Silvia C. Rodrigues; Eva Rohde; Sophie Rome; Kasper M.A. Rouschop; Aurelia Rughetti; Ashley E. Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A. Saugstad; Meike J. Saul; Raymond M. Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K. Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M. Silva; Agata Skowronek; Orman L. Snyder II; Rodrigo Pedro Soares; Barbara W. Sódar; Carolina Soekmadji; Javier Sotillo; Philip D. Stahl; Willem Stoorvogel; Shannon L. Stott; Erwin F. Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas W.M. van Balkom; Susanne G. van der Grein; Jan Van Deun; Martijn J.C. van Herwijnen; Kendall van Keuren-Jensen; Guillaume van Niel; Martin E. van Royen; Andre J. van Wijnen; M. Helena Vasconcelos; Ivan J. Vechetti Jr.; Tiago D. Veit; Laura J. Vella; Émilie Velot; Frederik J. Verweij; Beate Vestad; Jose L. Viñas; Tamás Visnovitz; Krisztina V. Vukman; Jessica Wahlgren; Dionysios C. Watson; Marca H.M. Wauben; Alissa Weaver; Jason P. Webber; Viktoria Weber; Ann M. Wehman; Daniel J. Weiss; Joshua A. Welsh; Sebastian Wendt; Asa M. Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R. Zheutlin; Antje M. Zickler; Pascale Zimmermann; Angela M. Zivkovic; Davide Zocco; and Ewa K. Zuba-Surma

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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade, Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, and Yu-Ying He

Manuscripts from 2018

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Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb., Simona D'Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, and Donatella Del Bufalo

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Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia, Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci, and Bruno Calabretta

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ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma., Shujun Han, Yibo Ren, Wangxiao He, Huadong Liu, Zhe Zhi, Xinliang Zhu, Tielin Yang, Yu Rong, Bohan Ma, Timothy J. Purwin, Zhenlin Ouyang, Caixia Li, Xun Wang, Xueqiang Wang, Huizi Yang, Yan Zheng, Andrew E. Aplin, Jiankang Liu, and Yongping Shao

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Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, and Andrew E. Aplin

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Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties., Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao, and Jay Whelan

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Differential impact of RB status on E2F1 reprogramming in human cancer., Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin E. Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, and Karen E. Knudsen

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miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential., Sara E. Meyer, David E. Muench, Andrew M. Rogers, Tess J. Newkold, Emily Orr, Eric O'Brien, John P. Perentesis, John G. Doench, Ashish Lal, Patrick J. Morris, Craig J. Thomas, Judy Lieberman, Edwina McGlinn, Bruce J. Aronow, Nathan Salomonis, and H. Leighton Grimes

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Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia, Valentina Minieri, Marco De Dominici, Marja T. Nevalainen, and Bruno Calabretta

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A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling, Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew A. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, and Lawrence N. Kwong

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PARP-1 regulates DNA repair factor availability., M J Schiewer; Amy C. Mandigo; Nicolas Gordon; Fangjin Huang; Sanchaika Gaur; Renée de Leeuw; Shuang G Zhao; Joseph Evans; Sumin Han; Theodore Parsons; Ruth Birbe; Peter McCue; Christopher McNair; Saswati N. Chand; Ylenia Cendon-Florez; Peter Gallagher; Jennifer J McCann; Neermala Poudel Neupane; Ayesha A Shafi; Emanuela Dylgjeri; Lucas J Brand; Tapio Visakorpi; Ganesh V Raj; Costas D. Lallas; Edouard J Trabulsi; Leonard G Gomella; Adam Dicker MD, PhD; William Kevin Kelly; Benjamin E Leiby; Beatrice Knudsen; Felix Y Feng; and Karen E Knudsen

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Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome, Guangxue Wang, Michael Gormley, Jing Qiao, Qian Zhao, Min Wang, Gabriele DiSante, Shengqiong Deng, Lin Dong, Timothy G. Pestell, Xiaoming Ju, Mathew C. Casimiro, Sankar Addya, Adam Ertel, Ayden Tozeren, Qinchuan Li, Zuoren Yu, and Richard G. Pestell

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EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer., Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, and Matthew D. Galsky

Manuscripts from 2017

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BCL-W has a fundamental role in B cell survival and lymphomagenesis., Clare M. Adams, Annette S. Kim, Ramkrishna Mitra, John K Choi, Jerald Z. Gong, and Christine M. Eischen

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Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW., Clare M. Adams; Ramkrishna Mitra; Jerald Z. Gong, MD; and Christine M. Eischen

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Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho., Reeti Behera, Amanpreet Kaur, Marie R. Webster, Suyeon Kim, Abibatou Ndoye, Curtis H. Kugel, Gretchen M. Alicea, Joshua Wang, Kanad Ghosh, Phil Cheng, Sofia Lisanti, Katie Marchbank, Vanessa Dang, Mitchell Levesque, Reinhard Dummer, Xiaowei Xu, Meenhard Herlyn, Andrew E. Aplin, Alexander Roesch, Cecilia Caino, Dario C. Altieri, and Ashani T. Weeraratna

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CKS1 expression in melanocytic nevi and melanoma, Anna A. Brożyna, Andrew Aplin, Cynthia Cohen, Grant Carlson, Andrew Joseph Page, Michael Murphy, Andrzej T. Slominski, and J. Andrew Carlson

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Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer., M Cecilia Caino, Jae Ho Seo, Yuan Wang, Dayana B. Rivadeneira, Dmitry I. Gabrilovich, Eui Tae Kim, Ashani T Weeraratna, Lucia R. Languino, and Dario C. Altieri

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Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis., Mathew C. Casimiro, Gabriele Disante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco-Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che-Hung Shen, Philipp E. Scherer, and Richard Pestell

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Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma., Hanyin Cheng, Vivian Chua, Connie Liao, Timothy J. Purwin, Mizue Terai, Ken Kageyama, Michael A. Davies, Takami Sato, and Andrew E. Aplin

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Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells., Kyle P Feeley, Clare M. Adams, Ramkrishna Mitra, and Christine M. Eischen

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Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, and Young Hye Kwon

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Letter by Horowitz Regarding Article, "Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability"., Arie Horowitz

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Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells., Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, and Zuoren Yu

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From EMT to HSC to AML: ZEB2 is a cell fate switch., Sara E. Meyer

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Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition., Ramkrishna Mitra, Xi Chen, Evan J. Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, and Christine M. Eischen

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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis., Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, D Craig Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, and Alessandra Castegna

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Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells, Carmela Paolillo, Zhaomei Mu, Giovanna Rossi, Matthew J. Schiewer, Thomas Nguyen, Laura Austin, Ettore Capoluongo, Karen E. Knudsen, Massimo Cristofanilli, and Paolo Fortina

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Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth, Timothy G. Pestell, Xuanmao Jiao, Mukesh Kumar, Amy R. Peck, Marco Prisco, Shengqiong Deng, Zhiping Li, Adam Ertel, Matthew C. Casimiro, Xiaoming Ju, Agnese Di Rocco, Gabriele Di Sante, Sanjay Katiyar, Alison Shupp, Michael P. Lisanti, Pooja Jain, Kongming Wu, Hallgeir Rui, Douglas Craig Hooper, Zuoren Yu, Aaron R. Goldman, David W. Speicher, Lisa Laury-Kleintop, and Richard G. Pestell

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Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification., Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, and Alexander Mazo

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Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle., Matthew J. Schiewer and Karen E. Knudsen

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Biological functions of CDK5 and potential CDK5 targeted clinical treatments., Alison Shupp, Mathew C. Casimiro, and Richard G. Pestell

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Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer., Jeffrey D. Thomas, Charles G. Longen, Halley M. Oyer, Nan Chen, Christina M. Maher, Joseph M. Salvino, Blase Kania, Kelsey N. Anderson, William F. Ostrander, Karen E. Knudsen, and Felix J. Kim

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DACH1 suppresses breast cancer as a negative regulator of CD44., Hanxiao Xu, Shengnan Yu, Xun Yuan, Jing Xiong, Dong Kuang, Richard Pestell, and Kongming Wu

Manuscripts from 2016

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The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma., Rajeev K Boregowda, Daniel J Medina, Elke Markert, Michael A Bryan, Wenjin Chen, Suzie Chen, Anna Rabkin, Michael J Vido, Samuel I Gunderson, Marina Chekmareva, David J Foran, Ahmed Lasfar, James S Goydos, and Karine A Cohen-Solal

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Tumor-associated stromal cells as key contributors to the tumor microenvironment., Karen M. Bussard, Lysette Mutkus, Kristina Stumpf, Candelaria Gomez-Manzano, and Frank C. Marini

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A neuronal network of mitochondrial dynamics regulates metastasis., M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, and Dario C. Altieri

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Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, and Dario C. Altieri

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A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice., Nicholas H Farina, Areg Zingiryan, Jacqueline A Akech, Cody J Callahan, Huimin Lu, Janet L Stein, Lucia R Languino, Gary S Stein, and Jane B Lian

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Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice., Brian C. Grieb, Kelli Boyd, Ramkrishna Mitra, and Christine M. Eischen

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v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1., Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C. Casimiro, Gabriele Disante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, and Richard G. Pestell

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The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development, Shuang Liu, Ramkrishna Mitra, Ming-Ming Zhao, Wenhong Fan, Christine M. Eischen, Feng Yin, and Zhongming Zhao

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Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury., Melissa T. Manners, Adam Ertel, Yuzhen Tian, and Seena K. Ajit

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Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes., Lucia Montorsi, Sandra Parenti, Lorena Losi, Fabrizio Ferrarini, Claudia Gemelli, A Rossi, Gianrocco Manco, Stefano Ferrari, Bruno Calabretta, Enrico Tagliafico, Tommaso Zanocco-Marani, and Alexis Grande

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Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer., Amanda R. Oran, Clare M. Adams, Xiao-Yong Zhang, Victoria J. Gennaro, Harla K. Pfeiffer, Hestia S. Mellert, Hans E. Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R. Gaballa, Chen Shen, Isidore Rigoutsos, Michael P. King, Justin L Cotney, Jamie J. Arnold, Suresh D. Sharma, Ubaldo E. Martinez-Outshoorn, Christopher R. Vakoc, Lewis A. Chodosh, James E. Thompson, James E. Bradner, Craig E. Cameron, Gerald S. Shadel, Christine M. Eischen, and Steven B. McMahon

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β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation., Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino

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The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis., Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, and Dario C. Altieri

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Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype., Amrita Singh, Carmine Fedele, Huimin Lu, Marja T. Nevalainen, James H. Keen, and Lucia R. Languino

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A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer., Qian Zhao, Shengqiong Deng, Guangxue Wang, Cuicui Liu, Lingyu Meng, Shanshan Qiao, Lei Shen, Yue Zhang, Jinhui Lü, Yuzhen Zhang, Min Wang, Richard Pestell, Chunli Liang, Zuoren Yu, and Wenshu Li

Manuscripts from 2015

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Consequence of the tumor-associated conversion to cyclin D1b., Michael A Augello, Lisa D Berman-Booty, Richard Carr, Akihiro Yoshida, Jeffry L Dean, M J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, and Karen E Knudsen

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Expression of Interferon Gamma by a Recombinant Rabies Virus Strongly Attenuates the Pathogenicity of the Virus via Induction of Type I Interferon., Darryll A Barkhouse; Samantha A Garcia; Emily K Bongiorno; Aurore Lebrun; Milosz Faber; and D Craig Hooper, PhD

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ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas., Claudia Capparelli, Sheera Rosenbaum, Lisa D. Berman-Booty, Amel Salhi, Nadège Gaborit, Tingting Zhan, Inna Chervoneva, Jason Roszik, Scott E. Woodman, Michael A. Davies, Yulius Y. Setiady, Iman Osman, Yosef Yarden, and Andrew E. Aplin

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Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis., Mathew C Casimiro, Gabriele Disante, Marco Crosariol, Emanuele Loro, William Dampier, Adam Ertel, Zuoren Yu, Elizabeth A Saria, Alexandros Papanikolaou, Z Li, Chenguang Wang, Sankar Addya, Michael P. Lisanti, Paolo Fortina, Robert D Cardiff, Aydin Tozeren, Erik S Knudsen, Andrew Arnold, and Richard Pestell

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Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma., Hanyin Cheng, Mizue Terai, Ken Kageyama, Shinji Ozaki, Peter McCue, Takami Sato, and Andrew E. Aplin

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The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module., Ke Chen, Kongming Wu, Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Disante, Shaohua Xu, Qiong Wang, Kevin Li, Xin Sun, Chongwen Xu, Zhiping Li, Mathew C. Casimiro, Adam Ertel, Sankar Addya, Peter McCue, Michael P. Lisanti, Chenguang Wang, Richard J. Davis, Graeme Mardon, and Richard Pestell

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Novel actions of next-generation taxanes benefit advanced stages of prostate cancer., Renée de Leeuw, Lisa D. Berman-Booty, Matthew J. Schiewer, Stephen J Ciment, Robert Den, Adam P. Dicker, William Kelly, Edouard J. Trabulsi, Costas D. Lallas, Leonard G. Gomella, and Karen E. Knudsen

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Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function., Felix Y. Feng, Johann S. de Bono, Mark A. Rubin, and Karen E Knudsen

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Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression., Irene Forno, Stefano Ferrero, Maria Veronica Russo, Giacomo Gazzano, Sara Giangiobbe, Emanuele Montanari, Alberto Del Nero, Bernardo Rocco, Giancarlo Albo, Lucia R Languino, Dario C Altieri, Valentina Vaira, and Silvano Bosari

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DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis., Jonathan F Goodwin, Vishal Kothari, Justin M Drake, Shuang Zhao, Emanuela Dylgjeri, Jeffry L. Dean, Matthew J. Schiewer, Christopher McNair, Jennifer K. Jones, Alvaro Aytes, Michael S. Magee, Adam E. Snook, Ziqi Zhu, Robert Den, Ruth C. Birbe, Leonard G. Gomella, Nicholas A. Graham, Ajay A. Vashisht, James A. Wohlschlegel, Thomas G. Graeber, R. Jeffrey Karnes, Mandeep Takhar, Elai Davicioni, Scott A. Tomlins, Cory Abate-Shen, Nima Sharifi, Owen N. Witte, Felix Y. Feng, and Karen E. Knudsen

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Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia., Zhiyong Liao, Lei Gu, Jenny Vergalli, Samanta A. Mariani, Marco De Dominici, Ravi K. Lokareddy, Ayush Dagvadorj, Puranik Purushottamachar, Peter A. McCue, Edouard J. Trabulsi, Costas D. Lallas, Shilpa Gupta, Elyse Ellsworth, Shauna Blackmon, Adam Ertel, Paolo Fortina, Benjamin E. Leiby, Guanjun Xia, Hallgeir Rui, David T. Hoang, Leonard G Gomella, Gino Cingolani, Vincent Njar, Nagarajan Pattabiraman, Bruno Calabretta, and Marja T. Nevalainen

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Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage., F Marampon, G L Gravina, Xiaoming Ju, A Vetuschi, R Sferra, Mathew C Casimiro, S Pompili, C Festuccia, A Colapietro, E Gaudio, E Di Cesare, V Tombolini, and Richard Pestell

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Antibiotics for cancer therapy., Richard Pestell and Albert A Rizvanov

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NF-κB Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in Melanoma., Yongping Shao, Kaitlyn Le, Hanyin Cheng, and Andrew E. Aplin

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DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1., Xin Sun, Shou-Ching Tang, Chongwen Xu, Chenguang Wang, Sida Qin, Ning Du, Jian Liu, Yiwen Zhang, Xiang Li, Gang Luo, Jie Zhou, Fei Xu, and Hong Ren

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Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism., Michele Tavecchio, Sofia Lisanti, Michael J Bennett, Lucia R Languino, and Dario C Altieri

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The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox., Michael J Vido and A E Aplin

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RAC1 P29S regulates PD-L1 expression in melanoma., Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, and Andrew E. Aplin

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Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1., Xuhui Zhang, Hai Wu, Jason R. Dobson, Gillian Browne, Deli Hong, Jacqueline Akech, Lucia R. Languino, Gary S. Stein, and Jane B. Lian

Manuscripts from 2014

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AR function in promoting metastatic prostate cancer., Michael A Augello, Robert B Den, and Karen E Knudsen

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Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity., Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, and Bruno Calabretta

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Genomics into Healthcare: the 5th Pan Arab Human Genetics Conference and 2013 Golden Helix Symposium., Paolo Fortina, Najib Al Khaja, Mahmoud Taleb Al Ali, Abdul Rezzak Hamzeh, Pratibha Nair, Federico Innocenti, George P. Patrinos, and Larry J. Kricka

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Hormone whodunit: clues for solving the case of intratumor androgen production., Karen E Knudsen

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miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer., Yuan Li, Chunli Liang, Haizhong Ma, Qian Zhao, Ying Lu, Zhendong Xiang, Li Li, Jie Qin, Yihan Chen, William C Cho, Richard G Pestell, Li Liang, and Zuoren Yu

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Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe., R Mu, Y-B Wang, M Wu, Y Yang, W Song, T Li, W-N Zhang, B Tan, A-L Li, N Wang, Q Xia, W-L Gong, Chenguang Wang, T Zhou, N Guo, Z-H Sang, and H-Y Li

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The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc., John R. Prensner, Wei Chen, Sumin Han, Matthew K. Iyer, Qi Cao, Vishal Kothari, Joseph R. Evans, Karen E. Knudsen, Michelle T. Paulsen, Mats Ljungman, Theodore S. Lawrence, Arul M. Chinnaiyan, and Felix Y. Feng

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Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women., Chun-Ping Qiu, Qing-Tao Lv, Samina Dongol, Chenguang Wang, and Jie Jiang

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The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness., Chellappagounder Thangavel; Ettickan Boopathi; Steve Ciment; Yi Liu; Raymond O'Neill; Ankur Sharma; Steve B McMahon; Hestia Mellert; Sankar Addya; Adam Ertel; Ruth Birbe; Paolo Fortina; Adam Dicker MD, PhD; Karen E Knudsen; and Robert Den MD

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Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells., Lifeng Tian, Chenguang Wang, Fred K Hagen, Michael Gormley, Sankar Addya, Raymond Soccio, Mathew C Casimiro, Jie Zhou, Michael J Powell, Ping Xu, Haiteng Deng, Anthony A Sauve, and Richard Pestell

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Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma., Ha Linh Vu and A E Aplin

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CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling., Tao Wang, Shuiming Guo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, and Ke Chen

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The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer., Tao Wang, Zhuo Liu, Shuiming Guo, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Shaohua Xu, Liping Wang, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, and Ke Chen

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The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer., A K Witkiewicz; D W Cox; D Rivadeneira; Adam Ertel; Paolo Fortina; Gordon Schwartz, MD, MBA, FACS; and E S Knudsen

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miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1., Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, and Richard Pestell

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Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case-control study., Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang, and Jinliang Xing

Manuscripts from 2013

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Cyclin D1 determines estrogen signaling in the mammary gland in vivo., Mathew C Casimiro, Chenguang Wang, Z Li, Gabriele Disante, Nicole E Willmart, Sankar Addya, Lei Chen, Yang Liu, Michael P. Lisanti, and Richard Pestell

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Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer., Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Disante, Zhiping Li, Hallgeir Rui, Andrew A Quong, Steven B McMahon, Haiteng Deng, Michael P Lisanti, Chenguang Wang, and Richard G Pestell

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Targeting cell cycle and hormone receptor pathways in cancer., C E S Comstock; M A Augello; J F Goodwin; R de Leeuw; M J Schiewer; W F Ostrander; R A Burkhart; A K McClendon; Peter McCue; Edouard J. Trabulsi; Costas D. Lallas; Leonard G Gomella, MD; M M Centenera; Jonathan Brody, MD; L M Butler; W D Tilley; and K E Knudsen, PhD

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Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs., Clement W Gnanadurai, Ming Zhou, Wenqi He, Christina M Leyson, Chien-Tsun Huang, Gregory Salyards, Stephen B Harvey, Zhenhai Chen, Biao He, Yang Yang, D C Hooper, Berhnard Dietzchold, and Zhen F Fu

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A STATement on vemurafenib-resistant melanoma., Edward J Hartsough and A E Aplin

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A TH1 immune response efficiently clears rabies virus from the CNS in the absence of inflammation, Aurore Lebrun, Rhonda Kean, Jianwei Li, and Douglas Craig Hooper

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Intracellular reprogramming of expression, glycosylation, and function of a plant-derived antiviral therapeutic monoclonal antibody., Jeong-Hwan Lee, Da-Young Park, Kyung-Jin Lee, Young-Kwan Kim, Yang-Kang So, Jae-Sung Ryu, Seung-Han Oh, Yeon-Soo Han, Kinarm Ko, Young-Kug Choo, Sung-Joo Park, Robert Brodzik, Kyoung-Ki Lee, Doo-Byoung Oh, Kyung-A Hwang, Hilary Koprowski, Yong Seong Lee, and Kisung Ko

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IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels., Aejaz Sayeed, Carmine Fedele, Marco Trerotola, Kirat K Ganguly, and Lucia R Languino

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Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver., Jonathan Schug, Lindsay B McKenna, Gabriel Walton, Nicholas Hand, Sarmistha Mukherjee, Kow Essuman, Zhongjie Shi, Yan Gao, Karen Markley, Momo Nakagawa, Vasumathi Kameswaran, Anastassios Vourekas, Joshua R Friedman, Klaus H Kaestner, and Linda E Greenbaum

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Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity., Duanwen Shen, Mingfeng Bai, Rui Tang, Baogang Xu, Xiaoming Ju, Richard Pestell, and Samuel Achilefu