Document Type
Article
Publication Date
3-27-2025
Abstract
Objective: To compare left ventricular (LV) and aortic (AO) pressures obtained using fluid-filled and high-fidelity solid-state pressure catheters in subjects undergoing left heart catheterization.
Materials and Methods: Twenty subjects scheduled for a left heart catheterization were enrolled and 18 subjects completed this IRB-approved study. LV and AO pressures were obtained using fluid-filled pressure catheter (standard-of-care) and high-fidelity solid-state pressure catheter synchronously. Pressure tracings were analyzed to measure LV systolic (LVSP), LV minimum-diastolic (LVMDP), LV end-diastolic (LVEDP), AO systolic (AOSP), and AO diastolic (AODP) pressures. Isovolumic contraction and relaxation rates (peak ± dp/dt) were derived from the pressure waveforms. Repeated measures of variance, post hoc tests with Bonferroni corrections, and Bland–Altman plots were used for comparisons.
Results: A significant main effect of the pressure catheter was noted for LVSP, LVMDP, and AOSP (p ≤ 0.025). The LVSP and AOSP measured with fluid-filled pressure catheters were higher by 6.6 ± 6.9 mmHg and 4.6 ± 5.2 mmHg in comparison to solid-state pressure catheter. In contrast, the LVMDP measurements were 3.5 ± 5.7 mmHg lower than the solid-state pressure catheter measurements. The isovolumic contraction (66.4 ± 116.0 mmHg/s) and relaxation rates (60.5 ± 113.5 mmHg/s) were not significantly different between catheter systems after Bonferroni corrections for multiple comparisons (p ≥ 0.06). The Bland–Altman analysis revealed a bias ranging from 0.8 to 6.6 mmHg.
Conclusions: Differences in LVSP, LVMDP, and AOSP were noted between the catheter systems but not for other pressure values and contraction/relaxation rates. Fluid-filled catheters overestimated true systolic pressures in the left ventricle and aorta.
Trial Registration: ClinicalTrials.gov identifier: NCT03245255
Recommended Citation
Machado, Priscilla; Cohen, Ira; Osler, Brian; McDonald, Maureen E.; Esposito, Cara; Davis, Marguerite; Fischman, David; Savage, Michael P.; Mehrotra, Praveen; Forsberg, Flemming; and Dave, Jaydev K., "Left Ventricular and Aortic Pressures Measured With Fluid-Filled and Solid-State Pressure Catheters: Similarities and Differences" (2025). Division of Cardiology Faculty Papers. Paper 172.
https://jdc.jefferson.edu/cardiologyfp/172
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author’s final published version in the Journal of Interventional Cardiology, Volume 2025, Issue 1, Article number 9359365.
The published version is available at https://doi.org/10.1155/joic/9359365. Copyright © 2025 Priscilla Machado et al. Journal of Interventional Cardiology published by John Wiley & Sons Ltd.