Document Type


Publication Date



This article has been peer reviewed. It is the authors' final version prior to publication in Clinical Hemorheology and Microcirculation

Volume 63, Issue 2, August 2015, Pages 149-152.

The published version is available at DOI: 10.3233/CH-152014. Copyright © IOS Press


Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesion to the endothelium.

Included in

Hematology Commons