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This article has not been peer reviewed. It is the authors' manuscript version prior to publication in Hematology/Oncology Clinics of North America

Volume 21, Issue 4, August 2007, Pages 633-45, v-vi.

The published version is available at DOI: 10.1016/j.hoc.2007.06.002. Copyright © WB Saunders


Platelet thrombi are central to the development of most vascular ischemic events. There is marked interindividual variation in platelet responsiveness, with some subjects displaying platelet hyperreactivity. An increasing number of reports indicate that there are laboratory measures of platelet function that predict clinical thrombotic events. Some, but not all, measures of platelet function are reproducible. Platelet hyperreactivity can be assessed with multiple stimuli in multiple assays and is more likely to be present in women and in subjects who have elevated fibrinogen levels.

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