Manuscripts from 2022
Genomic Features Underlie the Co-option of SVA Transposons as Cis-regulatory Elements in Human Pluripotent Stem Cells, Samantha M Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, and Marco Trizzino
Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases, Jenny L Carey and Lin Guo
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis, Zhicheng Cui, Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C Sacchettini, and Junjie Zhang
Recognition of the TDP-43 Nuclear Localization Signal by Importin α1/β, Steven G Doll, Hamed Meshkin, Alexander J Bryer, Fenglin Li, Ying-Hui Ko, Ravi K Lokareddy, Richard E Gillilan, Kushol Gupta, Juan R Perilla, and Gino Cingolani
Mesoscale Structure-Function Relationships in Mitochondrial Transcriptional Condensates, Marina Feric, Azadeh Sarfallah, Furqan Dar, Dmitry Temiakov, Rohit V. Pappu, and Tom Misteli
Differential recognition of canonical NF-κB dimers by Importin α3, Tyler J. Florio, Ravi K Lokareddy, Daniel P Yeggoni, Rajeshwer S Sankhala, Connor A Ott, Richard E Gillilan, and Gino Cingolani
Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors, Amandeep Girdhar and Lin Guo
Structure of the Pre-mRNA Leakage 39-kDa Protein Reveals a Single Domain of Integrated zf-C3HC and Rsm1 Modules, Hideharu Hashimoto, Daniel H. Ramirez, Ophélie Lautier, Natalie Pawlak, Günter Blobel, Benoît Palancade, and Erik W. Debler
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy, Hong Joo Kim, Payam Mohassel, Sandra Donkervoort, Lin Guo, Kevin O'Donovan, Maura Coughlin, Xaviere Lornage, Nicola Foulds, Simon R Hammans, A Reghan Foley, Charlotte M Fare, Alice F Ford, Masashi Ogasawara, Aki Sato, Aritoshi Iida, Pinki Munot, Gautam Ambegaonkar, Rahul Phadke, Dominic G O'Donovan, Rebecca Buchert, Mona Grimmel, Ana Töpf, Irina T Zaharieva, Lauren Brady, Ying Hu, Thomas E Lloyd, Andrea Klein, Maja Steinlin, Alice Kuster, Sandra Mercier, Pascale Marcorelles, Yann Péréon, Emmanuelle Fleurence, Adnan Manzur, Sarah Ennis, Rosanna Upstill-Goddard, Luca Bello, Cinzia Bertolin, Elena Pegoraro, Leonardo Salviati, Courtney E French, Andriy Shatillo, F Lucy Raymond, Tobias B Haack, Susana Quijano-Roy, Johann Böhm, Isabelle Nelson, Tanya Stojkovic, Teresinha Evangelista, Volker Straub, Norma B Romero, Jocelyn Laporte, Francesco Muntoni, Ichizo Nishino, Mark A Tarnopolsky, James Shorter, Carsten G Bönnemann, and J Paul Taylor
Terminase Subunits from the Pseudomonas-Phage E217, Ravi K Lokareddy, Chun-Feng David Hou, Steven G Doll, Fenglin Li, Richard E Gillilan, Francesca Forti, David S Horner, Federica Briani, and Gino Cingolani
Viral Small Terminase: A Divergent Structural Framework for a Conserved Biological Function., Ravi K. Lokareddy, Chun-Feng David Hou, Fenglin Li, Ruoyu Yang, and Gino Cingolani
Structural enzymology of cholesterol biosynthesis and storage., Tao Long, Erik W Debler, and Xiaochun Li
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy, Elana Molotsky, Y Liu, Andrew P Lieberman, and Diane E Merry
Functions of ADP-ribose transferases in the maintenance of telomere integrity, Daniela Muoio, Natalie Laspata, and Elise Fouquerel
Evidence for Paracrine Protective Role of Exogenous αA-Crystallin in Retinal Ganglion Cells, Madhu Nath, Zachary B Sluzala, Ashutosh S Phadte, Yang Shan, Angela M Myers, and Patrice E Fort
Young Transposable Elements Rewired Gene Regulatory Networks in Human and Chimpanzee Hippocampal Intermediate Progenitors, Sruti Patoori, Samantha M Barnada, Christopher Large, John I Murray, and Marco Trizzino
Enhanced Membrane Binding of Oncogenic G Protein αqQ209L Confers Resistance to Inhibitor YM-254890, Clinita E. Randolph, Morgan B. Dwyer, Jenna L. Aumiller, Alethia J. Dixon, Asuka Inoue, Patrick Osei-Owusu, and Philip B. Wedegaertner
ISC10, an Inhibitor of the SMK1 MAPK, Prevents Activation Loop Autophosphorylation and Substrate Phosphorylation Through Separate Mechanisms, Abhimannyu Rimal, Thomas M Swayne, Zeal P Kamdar, Madison A Tewey, and Edward Winter
The role of ubiquitination in spinal and bulbar muscular atrophy., Medha Sengupta, Anna Pluciennik, and Diane E. Merry
Viral Ejection Proteins: Mosaically Conserved, Conformational Gymnasts, Nicholas A. Swanson, Chun-Feng Hou, and Gino Cingolani
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes, Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes., Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino
G Protein-Coupled Receptor Kinase 6 (GRK6) Regulates Insulin Processing and Secretion via Effects on Proinsulin Conversion to Insulin, Matthew J Varney, Wouter Steyaert, Paul J Coucke, Joris R Delanghe, David E Uehling, Babu Joseph, Richard Marcellus, Rima Al-Awar, and Jeffrey L Benovic
Mechanisms of mitochondrial promoter recognition in humans and other mammalian species, Angelica Zamudio-Ochoa, Yaroslav I Morozov, Azadeh Sarfallah, Michael Anikin, and Dmitry Temiakov
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis., Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, and Michael Niederweis
Manuscripts from 2021
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation., Danique Beijer, Hong Joo Kim, Lin Guo, Kevin O'Donovan, Inès Mademan, Tine Deconinck, Kristof Van Schil, Charlotte M Fare, Lauren E Drake, Alice F Ford, Andrzej Kochański, Dagmara Kabzińska, Nicolas Dubuisson, Peter Van den Bergh, Nicol C Voermans, Richard Jlf Lemmers, Silvère M van der Maarel, Devon Bonner, Jacinda B Sampson, Matthew T Wheeler, Anahit Mehrabyan, Steven Palmer, Peter De Jonghe, James Shorter, J Paul Taylor, and Jonathan Baets
Historical Perspective of the G Protein-Coupled Receptor Kinase Family., Jeffrey L Benovic
Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development, Gregory L Branigan, Kelly S Olsen, Isabella Burda, Matthew W Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D D'Antonio, Ian E Briggs, and Angela J DiBenedetto
A stress-free strategy to correct point mutations in patient iPS cells, Jingli Cai, Elizabeth Kropf, Ya-Ming Hou, and Lorraine Iacovitti
Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP, Christine E Carbone, Anna B Loveland, Howard Gamper, Ya-Ming Hou, Gabriel Demo, and Andrei A Korostelev
Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining, Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, and Richard T Pomerantz
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair, Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, and Richard Pomerantz
Dna polymerase θ: A cancer drug target with reverse transcriptase activity, Xiaojiang Chen and Richard T. Pomerantz
Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation., Gabriel Demo, Howard Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, and Andrei A. Korostelev
Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates., Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, and Steven B. McMahon
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design., Lukas Friedrich, Gino Cingolani, Ying-Hui Ko, Mariaclara Iaselli, Morena Miciaccia, Maria Grazia Perrone, Konstantin Neukirch, Veronika Bobinger, Daniel Merk, Robert Klaus Hofstetter, Oliver Werz, Andreas Koeberle, Antonio Scilimati, and Gisbert Schneider
An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference., Miki Fujioka, Anastasiya Nezdyur, and James B. Jaynes
Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA., Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, and Ya-Ming Hou
Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms, Jennifer Guerrero-Santoro, Jian Ming Khor, Ayşe Haruka Açıkbaş, James B. Jaynes, and Charles A Ettensohn
TERA-Seq: true end-to-end sequencing of native RNA molecules for transcriptome characterization, Fadia Ibrahim, Jan Oppelt, Manolis Maragkakis, and Zissimos Mourelatos
DNA Mismatch Repair and its Role in Huntington's Disease, Ravi R Iyer and Anna Pluciennik
Targeting oncogenic gαq/11 in uveal melanoma, Dominic Lapadula and Jeffrey L Benovic
Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, and Jeffrey L Benovic
Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness, Pratyusha Mandal, Lynsey Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher Dillon, Heather Koehler, Linda Roback, Emad S Alnemri, Douglas Green, and Edward Mocarski
Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression, Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R. Buskirk, and Ya-Ming Hou
Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis., Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L.J. Tybulewicz, Teresa Fernandes-Alnemri, and Emad S. Alnemri
Three-dimensional structure of human cyclooxygenase (hCOX)-1., Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, and Antonio Scilimati
The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS., Joseph D Orkin, Michael J Montague, Daniela Tejada-Martinez, Marc de Manuel, Javier Del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A Hodgson, Mareike C Janiak, Lukas F K Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H Perry, Carmen Soto Valverde, Jia Tang, Wesley C Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès-Bonet, Roman Krawetz, and Amanda D Melin
Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders, Luca Pagliaroli, Patrizia Porazzi, Alyxandra T Curtis, Chiara Scopa, Harald M M Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A Welsh, Sarah Offley, Connor A Ott, Bruno Calabretta, Samantha A Brugmann, Gijs W E Santen, and Marco Trizzino
The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination, Luca Pagliaroli and Marco Trizzino
Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression., Kalpana Rajanala, Lauren M. Klayman, and Philip B. Wedegaertner
Expression and purification of phage T7 ejection proteins for cryo-EM analysis, Nicholas A. Swanson, Ravi K Lokareddy, Fenglin Li, Chun-Feng Hou, Mikhail Pavlenok, Michael Niederweis, and Gino Cingolani
Manuscripts from 2020
Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages., Ardeshir Ariana, Norah A Alturki, Stephanie Hajjar, Deborah J Stumpo, Christopher Tiedje, Emad S Alnemri, Matthias Gaestel, Perry J Blackshear, and Subash Sad
Purification and Use of tRNA for Enzymatic Post-translational Addition of Amino Acids to Proteins., Irem Avcilar-Kucukgoze, Howard Gamper, Ya-Ming Hou, and Anna Kashina
Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups, Christine R Fisher, David E Lowe, Todd G Smith, Yong Yang, Christina L Hutson, Christoph Wirblich, Gino Cingolani, and Matthias J. Schnell
A Label-Free Assay for Aminoacylation of tRNA, Howard Gamper and Ya-Ming Hou
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion, Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion., Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt
Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses., Lu Liu, Shuaiyi Chen, Miao Yu, Chenxu Ge, Mengmeng Ren, Boya Liu, Xin Yang, Thomas W Christian, Ya-Ming Hou, Junhua Zou, Wei-Guo Zhu, and Jianyuan Luo
Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment., Ravi K Lokareddy, Ying Hui Ko, Nathaniel Hong, Steven G Doll, Marcin Paduch, Michael Niederweis, Anthony A Kossiakoff, and Gino Cingolani
Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation., Marzia Niazi, Tyler J. Florio, Ruoyu Yang, Ravi K. Lokareddy, Nicholas A. Swanson, Richard E. Gillilan, and Gino Cingolani
Mg2+-Dependent Methyl Transfer by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Study, Agata P Perlinska, Marcin Kalek, Thomas Christian, Ya-Ming Hou, and Joanna I Sulkowska
Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells, Fabio Quaglia, Shiv Ram Krishn, George G. Daaboul, Srawasti Sarker, Raffaella Pippad, Josep Domingo-Domenech, Gaurav Kumar, Paolo Fortina, Peter McCuee, William K. Kelly, Himisha Beltran, Qin Liu, and Lucia R. Languinoa
Manuscripts from 2019
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy., Frederick J. Arnold, Anna Pluciennik, and Diane E. Merry
Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA., Gino Cingolani, Michael McCauley, Anna Lobley, Alexander J Bryer, Jordan Wesolowski, Deanna L Greco, Ravi K Lokareddy, Erik Ronzone, Juan R Perilla, and Fabienne Paumet
Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase., Travis Eisemann, Marie-France Langelier, and John M. Pascal
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC., Victoria J. Gennaro, Helen Wedegaertner, and Steven B. McMahon
Codon-Specific Translation by m1G37 Methylation of tRNA, Ya-Ming Hou, Isao Masuda, and Howard Gamper
Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation, Julia L Jones, Katharina B. Hofmann, Andrew T. Cowan, Dmitry Temiakov, Patrick Cramer, and Michael Anikin
tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance., Isao Masuda, Ryuma Matsubara, Thomas Christian, Enrique R. Rojas, Srujana S. Yadavalli, Lisheng Zhang, Mark Goulian, Leonard J. Foster, Kerwyn Casey Huang, and Ya-Ming Hou
Heme and hemoglobin utilization by Mycobacterium tuberculosis., Avishek Mitra, Ying-Hui Ko, Gino Cingolani, and Michael Niederweis
Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, and Robert W Burgess
Gasdermins in Apoptosis: New players in an Old Game., Corey Rogers and Emad S. Alnemri
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation., Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, and Emad S. Alnemri
Characterization of resistance to a potent D-peptide HIV entry inhibitor., Amanda R Smith, Matthew T Weinstock, Amanda E Siglin, Frank G Whitby, J Nicholas Francis, Christopher P Hill, Debra M Eckert, Michael J Root, and Michael S Kay
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes, Chong Sun, Jie Song, Yanjun Jiang, Chongbo Zhao, Jiahong Lu, Yuxin Li, Yin Wang, Mingshi Gao, Jianying Xi, Sushan Luo, Meixia Li, Kevin Donaldson, Stephanie N. Oprescu, Thomas P. Slavin, Sansan Lee, Pilar L. Magoulas, Andrea M. Lewis, Lisa Emrick, Seema R. Lalani, Zhiyv Niu, Megan L. Landsverk, Magdalena Walkiewicz, Richard E. Person, Hui Mei, Jill A. Rosenfeld, Yaping Yang, Anthony Antonellis, Ya-Ming Hou, Jie Lin, and Victor W. Zhang
A unique role for clathrin light chain A in cell spreading and migration., Oxana M. Tsygankova and James H. Keen
How to Untie a Protein Knot., Sitao Yin, Brittiny Dhital, and Ya-Ming Hou
Manuscripts from 2018
Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis., Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, and Subash Sad
SUMO-mediated regulation of NLRP3 modulates inflammasome activity., Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad S Alnemri, Marcin Drag, Yuan Chen, and Pascal Meier
Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase, Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C. Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S. Patel, Richard H. Ebright, and Bryce E. Nickels
Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K, Lan Cheng, Moza Al-Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning, Chris Peers, and Natalia A Riobo-Del Galdo
tRNA 3'-amino-tailing for stable amino acid attachment., Howard Gamper and Ya-Ming Hou
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells., Victoria J. Gennaro, Timothy J. Stanek, Amy R. Peck, Yunguang Sun, Feng Wang, Shuo Qie, Karen E. Knudsen, Hallgeir Rui, Tauseef Butt, J. Alan Diehl, and Steven B. McMahon
Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio de Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, and Douglas G. Tilley
Structural basis of mitochondrial transcription., Hauke S. Hillen, Dmitry Temiakov, and Patrick Cramer
Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia., Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R. Manning, and Natalia A. Riobo-Del Galdo
Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response., Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, and Laurie K. Read
In Vitro growth of human ovarian follicles for fertility preservation, Diego Marin, Min Yang, and Tianren Wang
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation., Scott J. Morin, Xin Tao, Diego Marin, Yiping Zhan, Jessica Landis, Jenna Bedard, Richard T. Scott, and Emre Seli
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, and Edward Winter
Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy., Kristin N. Parent, Jason R. Schrad, and Gino Cingolani
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes., Ian Gaël Rodrigue-Gervais, Karine Doiron, Claudia Champagne, Lindsey Mayes, Gabriel André Leiva-Torres, Paulin Vanié, Todd Douglas, Silvia M. Vidal, Emad S. Alnemri, and Maya Saleh
Manuscripts from 2017
Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors., Koree W. Ahn and Michael J. Root
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers, Angelina A. Akishina, J. E. Vorontsova, Roman O. Cherezov, Ilja B. Mertsalov, Olga G. Zatsepina, Mikhail S. Slezinger, Vladislav M. Panin, Svetlana Petruk, Grigori N. Enikolopov, Alexander M. Mazo, Olga B. Simonova, and Boris A. Kuzin
The kinetic mechanism of bacterial ribosome recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, and Barry S. Cooperman
Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, and Andrew E. Aplin
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)., Gino Cingolani, Andrea Panella, Maria Grazia Perrone, Paola Vitale, Giuseppe Di Mauro, Cosimo G G. Fortuna, Roger S. Armen, Savina Ferorelli, William L. Smith, and Antonio Scilimati
The Structure and C=C Vibrational Frequencies of the all- trans Polyenes C2nH2n+2(n=2-15), C2nH2n(Me)2(n=2-13), and C2nH2n(tert-Butyl)2(n=2-5): Computational Results, George R. De Maré, Niny Z. Rao, and Charles W. Block
Functional selectivity of GPCR-directed drug action through location bias., Roshanak Irannejad, Veronica Pessino, Delphine Mika, Bo Huang, Philip B. Wedegaertner, Marco Conti, and Mark von Zastrow
