Follow

Manuscripts from 2021

PDF

Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation., Danique Beijer, Hong Joo Kim, Lin Guo, Kevin O'Donovan, Inès Mademan, Tine Deconinck, Kristof Van Schil, Charlotte M Fare, Lauren E Drake, Alice F Ford, Andrzej Kochański, Dagmara Kabzińska, Nicolas Dubuisson, Peter Van den Bergh, Nicol C Voermans, Richard Jlf Lemmers, Silvère M van der Maarel, Devon Bonner, Jacinda B Sampson, Matthew T Wheeler, Anahit Mehrabyan, Steven Palmer, Peter De Jonghe, James Shorter, J Paul Taylor, and Jonathan Baets

PDF

Historical Perspective of the G Protein-Coupled Receptor Kinase Family., Jeffrey L Benovic

PDF

A stress-free strategy to correct point mutations in patient iPS cells, Jingli Cai, Elizabeth Kropf, Ya-Ming Hou, and Lorraine Iacovitti

PDF

Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining, Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, and Richard T Pomerantz

PDF

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair, Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, and Richard Pomerantz

PDF

Dna polymerase θ: A cancer drug target with reverse transcriptase activity, Xiaojiang Chen and Richard T. Pomerantz

PDF

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation., Gabriel Demo, Howard Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, and Andrei A. Korostelev

PDF

Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates., Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, and Steven B. McMahon

PDF

Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design., Lukas Friedrich, Gino Cingolani, Ying-Hui Ko, Mariaclara Iaselli, Morena Miciaccia, Maria Grazia Perrone, Konstantin Neukirch, Veronika Bobinger, Daniel Merk, Robert Klaus Hofstetter, Oliver Werz, Andreas Koeberle, Antonio Scilimati, and Gisbert Schneider

PDF

An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference., Miki Fujioka, Anastasiya Nezdyur, and James B. Jaynes

PDF

Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA., Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, and Ya-Ming Hou

PDF

Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms, Jennifer Guerrero-Santoro, Jian Ming Khor, Ayşe Haruka Açıkbaş, James B. Jaynes, and Charles A Ettensohn

PDF

DNA Mismatch Repair and its Role in Huntington's Disease, Ravi R Iyer and Anna Pluciennik

PDF

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression, Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R. Buskirk, and Ya-Ming Hou

PDF

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis., Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L.J. Tybulewicz, Teresa Fernandes-Alnemri, and Emad S. Alnemri

PDF

Three-dimensional structure of human cyclooxygenase (hCOX)-1., Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, and Antonio Scilimati

PDF

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS., Joseph D Orkin, Michael J Montague, Daniela Tejada-Martinez, Marc de Manuel, Javier Del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A Hodgson, Mareike C Janiak, Lukas F K Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H Perry, Carmen Soto Valverde, Jia Tang, Wesley C Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès-Bonet, Roman Krawetz, and Amanda D Melin

PDF

The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination, Luca Pagliaroli and Marco Trizzino

Manuscripts from 2020

PDF

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages., Ardeshir Ariana, Norah A Alturki, Stephanie Hajjar, Deborah J Stumpo, Christopher Tiedje, Emad S Alnemri, Matthias Gaestel, Perry J Blackshear, and Subash Sad

PDF

Purification and Use of tRNA for Enzymatic Post-translational Addition of Amino Acids to Proteins., Irem Avcilar-Kucukgoze, Howard Gamper, Ya-Ming Hou, and Anna Kashina

PDF

Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups, Christine R Fisher, David E Lowe, Todd G Smith, Yong Yang, Christina L Hutson, Christoph Wirblich, Gino Cingolani, and Matthias J. Schnell

PDF

A Label-Free Assay for Aminoacylation of tRNA, Howard Gamper and Ya-Ming Hou

PDF

Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion, Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt

PDF

Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion., Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt

PDF

Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses., Lu Liu, Shuaiyi Chen, Miao Yu, Chenxu Ge, Mengmeng Ren, Boya Liu, Xin Yang, Thomas W Christian, Ya-Ming Hou, Junhua Zou, Wei-Guo Zhu, and Jianyuan Luo

PDF

Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment., Ravi K Lokareddy, Ying Hui Ko, Nathaniel Hong, Steven G Doll, Marcin Paduch, Michael Niederweis, Anthony A Kossiakoff, and Gino Cingolani

PDF

Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation., Marzia Niazi, Tyler J. Florio, Ruoyu Yang, Ravi K. Lokareddy, Nicholas A. Swanson, Richard E. Gillilan, and Gino Cingolani

PDF

Mg2+-Dependent Methyl Transfer by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Study, Agata P Perlinska, Marcin Kalek, Thomas Christian, Ya-Ming Hou, and Joanna I Sulkowska

PDF

Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells, Fabio Quaglia, Shiv Ram Krishn, George G. Daaboul, Srawasti Sarker, Raffaella Pippad, Josep Domingo-Domenech, Gaurav Kumar, Paolo Fortina, Peter McCuee, William K. Kelly, Himisha Beltran, Qin Liu, and Lucia R. Languinoa

Manuscripts from 2019

PDF

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy., Frederick J. Arnold, Anna Pluciennik, and Diane E. Merry

PDF

Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA., Gino Cingolani, Michael McCauley, Anna Lobley, Alexander J Bryer, Jordan Wesolowski, Deanna L Greco, Ravi K Lokareddy, Erik Ronzone, Juan R Perilla, and Fabienne Paumet

PDF

Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase., Travis Eisemann, Marie-France Langelier, and John M. Pascal

PDF

Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC., Victoria J. Gennaro, Helen Wedegaertner, and Steven B. McMahon

PDF

Codon-Specific Translation by m1G37 Methylation of tRNA, Ya-Ming Hou, Isao Masuda, and Howard Gamper

PDF

Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation, Julia L Jones, Katharina B. Hofmann, Andrew T. Cowan, Dmitry Temiakov, Patrick Cramer, and Michael Anikin

PDF

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance., Isao Masuda, Ryuma Matsubara, Thomas Christian, Enrique R. Rojas, Srujana S. Yadavalli, Lisheng Zhang, Mark Goulian, Leonard J. Foster, Kerwyn Casey Huang, and Ya-Ming Hou

PDF

Heme and hemoglobin utilization by Mycobacterium tuberculosis., Avishek Mitra, Ying-Hui Ko, Gino Cingolani, and Michael Niederweis

PDF

Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, and Robert W Burgess

PDF

Gasdermins in Apoptosis: New players in an Old Game., Corey Rogers and Emad S. Alnemri

PDF

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation., Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, and Emad S. Alnemri

PDF

Characterization of resistance to a potent D-peptide HIV entry inhibitor., Amanda R Smith, Matthew T Weinstock, Amanda E Siglin, Frank G Whitby, J Nicholas Francis, Christopher P Hill, Debra M Eckert, Michael J Root, and Michael S Kay

PDF

Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes, Chong Sun, Jie Song, Yanjun Jiang, Chongbo Zhao, Jiahong Lu, Yuxin Li, Yin Wang, Mingshi Gao, Jianying Xi, Sushan Luo, Meixia Li, Kevin Donaldson, Stephanie N. Oprescu, Thomas P. Slavin, Sansan Lee, Pilar L. Magoulas, Andrea M. Lewis, Lisa Emrick, Seema R. Lalani, Zhiyv Niu, Megan L. Landsverk, Magdalena Walkiewicz, Richard E. Person, Hui Mei, Jill A. Rosenfeld, Yaping Yang, Anthony Antonellis, Ya-Ming Hou, Jie Lin, and Victor W. Zhang

PDF

A unique role for clathrin light chain A in cell spreading and migration., Oxana M. Tsygankova and James H. Keen

PDF

How to Untie a Protein Knot., Sitao Yin, Brittiny Dhital, and Ya-Ming Hou

Manuscripts from 2018

PDF

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis., Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, and Subash Sad

PDF

SUMO-mediated regulation of NLRP3 modulates inflammasome activity., Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad S Alnemri, Marcin Drag, Yuan Chen, and Pascal Meier

PDF

Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase, Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C. Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S. Patel, Richard H. Ebright, and Bryce E. Nickels

PDF

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K, Lan Cheng, Moza Al-Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning, Chris Peers, and Natalia A Riobo-Del Galdo

PDF

tRNA 3'-amino-tailing for stable amino acid attachment., Howard Gamper and Ya-Ming Hou

PDF

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells., Victoria J. Gennaro, Timothy J. Stanek, Amy R. Peck, Yunguang Sun, Feng Wang, Shuo Qie, Karen E. Knudsen, Hallgeir Rui, Tauseef Butt, J. Alan Diehl, and Steven B. McMahon

PDF

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio de Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, and Douglas G. Tilley

PDF

Structural basis of mitochondrial transcription., Hauke S. Hillen, Dmitry Temiakov, and Patrick Cramer

PDF

Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia., Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R. Manning, and Natalia A. Riobo-Del Galdo

PDF

Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response., Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, and Laurie K. Read

PDF

In Vitro growth of human ovarian follicles for fertility preservation, Diego Marin, Min Yang, and Tianren Wang

PDF

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation., Scott J. Morin, Xin Tao, Diego Marin, Yiping Zhan, Jessica Landis, Jenna Bedard, Richard T. Scott, and Emre Seli

PDF

The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, and Edward Winter

PDF

Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy., Kristin N. Parent, Jason R. Schrad, and Gino Cingolani

PDF

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes., Ian Gaël Rodrigue-Gervais, Karine Doiron, Claudia Champagne, Lindsey Mayes, Gabriel André Leiva-Torres, Paulin Vanié, Todd Douglas, Silvia M. Vidal, Emad S. Alnemri, and Maya Saleh

Manuscripts from 2017

PDF

Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors., Koree W. Ahn and Michael J. Root

PDF

Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers, Angelina A. Akishina, J. E. Vorontsova, Roman O. Cherezov, Ilja B. Mertsalov, Olga G. Zatsepina, Mikhail S. Slezinger, Vladislav M. Panin, Svetlana Petruk, Grigori N. Enikolopov, Alexander M. Mazo, Olga B. Simonova, and Boris A. Kuzin

PDF

The kinetic mechanism of bacterial ribosome recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, and Barry S. Cooperman

PDF

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, and Andrew E. Aplin

PDF

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)., Gino Cingolani, Andrea Panella, Maria Grazia Perrone, Paola Vitale, Giuseppe Di Mauro, Cosimo G G. Fortuna, Roger S. Armen, Savina Ferorelli, William L. Smith, and Antonio Scilimati

PDF

The Structure and C=C Vibrational Frequencies of the all- trans Polyenes C2nH2n+2(n=2-15), C2nH2n(Me)2(n=2-13), and C2nH2n(tert-Butyl)2(n=2-5): Computational Results, George R. De Maré, Niny Z. Rao, and Charles W. Block

PDF

Functional selectivity of GPCR-directed drug action through location bias., Roshanak Irannejad, Veronica Pessino, Delphine Mika, Bo Huang, Philip B. Wedegaertner, Marco Conti, and Mark von Zastrow

PDF

Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G., Nobuhiro Iwakura, Takeshi Yokoyama, Fabio Quaglia, Kaoru Mitsuoka, Kazuhiro Mio, Hideki Shigematsu, Mikako Shirouzu, Akira Kaji, and Hideko Kaji

PDF

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5., Konstantin E. Komolov, Yang Du, Nguyen Minh Duc, Robin M. Betz, João P.G.L.M. Rodrigues, Ryan D. Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M. Adams, Ron O. Dror, Ka Young Chung, Brian K. Kobilka, and Jeffrey L. Benovic

PDF

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70., Taosui Li, Jacob W Hodgson, Svetlana Petruk, Alexander Mazo, and Hugh W Brock

PDF

Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation., Ravi K. Lokareddy, Rajeshwer S. Sankhala, Ankoor Roy, Pavel V. Afonine, Tina Motwani, Carolyn M M. Teschke, Kristin N. Parent, and Gino Cingolani

PDF

A genetically encoded fluorescent tRNA is active in live-cell protein synthesis., Isao Masuda, Takao Igarashi, Reiko Sakaguchi, Ram G. Nitharwal, Ryuichi Takase, Kyu Young Han, Benjamin J. Leslie, Cuiping Liu, Howard Gamper, Taekjip Ha, Suparna Sanyal, and Ya-Ming Hou

PDF

Detection and molecular status of Isospora sp. from the domestic pigeon (Columba livia domestica)., Ryuma Matsubara, Yasuhiro Fukuda, Fumi Murakoshi, Osamu Nomura, Toru Suzuki, Chika Tada, and Yutaka Nakai

PDF

Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands., Jacob Peacock and James B Jaynes

PDF

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death., Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, and Emad S. Alnemri

PDF

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1., Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, and Gino Cingolani

PDF

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans., Jianjun Wang, Jiansong Luo, Dipendra K. Aryal, William C. Wetsel, Richard Nass, and Jeffrey L. Benovic

PDF

Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms., Wei Wu, Rajeshwer S. Sankhala, Tyler J Florio, Lixin Zhou, Nhan L.T. Nguyen, Ravi K. Lokareddy, Gino Cingolani, and Nelly Panté

PDF

The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms., Jill M. Yersak, Heather L. Montie, Erica S. Chevalier-Larsen, Yuhong Liu, Lan Huang, Martin Rechsteiner, and Diane E. Merry

PDF

Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation., Sungsoo M. Yoo, Arash Latifkar, Richard A. Cerione, and Marc A. Antonyak

Manuscripts from 2016

PDF

Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria., David H. Ardell and Ya-Ming Hou

Link

Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans., Miki Fujioka, Hemlata Mistry, Paul Schedl, and James B. Jaynes

PDF

Chromatin proteins and RNA are associated with DNA during all phases of mitosis., Kathryn L Black, Svetlana Petruk, Tyler K Fenstermaker, Jacob W Hodgson, Jeffrey L Caplan, Hugh W Brock, and Alexander Mazo

PDF

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus., George J. Leslie, Jianbin Wang, Max W. Richardson, Beth S. Haggarty, Kevin L. Hua, Jennifer Duong, Anthony J. Secreto, Andrea P.O. Jordon, Josephine Romano, Kritika E. Kumar, Joshua J. DeClercq, Philip D. Gregory, Carl H. June, Michael J. Root, James L. Riley, Michael C. Holmes, and James A. Hoxie

PDF

Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction., Cuiping Liu, Aaron J Stonestrom, Thomas Christian, Jeongsik Yong, Ryuichi Takase, Ya-Ming Hou, and Xiaolu Yang

PDF

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation., Dmitry Ratner, M Pontus A Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, and Egil Lien

PDF

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage., Amanda A Riccio, Gino Cingolani, and John M Pascal

PDF

The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins., Jessica H Shinn-Thomas, Jacob J Del Campo, Jianjun Wang, and William A Mohler

PDF

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor., Xufan Tian, Roshanak Irannejad, Shanna L. Bowman, Yang Du, Manojkumar A. Puthenveedu, Mark von Zastrow, and Jeffrey L. Benovic

PDF

A PARP1-ERK2 synergism is required for the induction of LTP., L Visochek, G Grigoryan, A Kalal, H Milshtein-Parush, N Gazit, I Slutsky, A Yeheskel, A Shainberg, A Castiel, R Seger, Marie-France Langelier, F Dantzer, Pascal Jabbour MD, M Segal, and M Cohen-Armon

Manuscripts from 2015

PDF

Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, and M G Mahoney

PDF

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease., Jason P Chua, Satya L Reddy, Zhigang Yu, Elisa Giorgetti, Heather L Montie, Sarmistha Mukherjee, Jake Higgins, Richard C McEachin, Diane M Robins, Diane E Merry, Jorge A Iñiguez-Lluhí, and Andrew P Lieberman

PDF

Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy., Ya-Ming Hou, , and Wei Yang

PDF

Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity., Yuan-Yuan Jin, Jade Andrade, and Eric Wickstrom

PDF

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3., Seokwon Kang, Teresa Fernandes-Alnemri, Corey Rogers, Lindsey Mayes, Ying Wang, Christopher Dillon, Linda Roback, William Kaiser, Andrew Oberst, Junji Sagara, Katherine A Fitzgerald, Douglas R Green, Jianke Zhang, Edward S Mocarski, and Emad S Alnemri

PDF

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases, Konstantin E. Komolov, Anshul Bhardwaj, and Jeffrey L. Benovic

Link

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G., Takahide Kouno, Elizabeth M Luengas, Megumi Shigematsu, Shivender M D Shandilya, JingYing Zhang, Luan Chen, Mayuko Hara, Celia A Schiffer, Reuben S Harris, and Hiroshi Matsuo

PDF

Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins., Annemarie Kralt, Noorjahan B Jagalur, Vincent van den Boom, Ravi K Lokareddy, Anton Steen, Gino Cingolani, Maarten Fornerod, and Liesbeth M Veenhoff

PDF

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway., S Malik, R G deRubio, M Trembley, R Irannejad, Philip B Wedegaertner, and A V Smrcka

PDF

The rise and fall of poly(ADP-ribose): An enzymatic perspective., John M. Pascal and Tom Ellenberger

PDF

Diversification of importin-α isoforms in cellular trafficking and disease states., Ruth A. Pumroy and Gino Cingolani