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Manuscripts from 2022

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Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases, Jenny L Carey and Lin Guo

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Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis, Zhicheng Cui, Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C Sacchettini, and Junjie Zhang

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Differential recognition of canonical NF-κB dimers by Importin α3, Tyler J. Florio, Ravi K Lokareddy, Daniel P Yeggoni, Rajeshwer S Sankhala, Connor A Ott, Richard E Gillilan, and Gino Cingolani

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Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy, Hong Joo Kim, Payam Mohassel, Sandra Donkervoort, Lin Guo, Kevin O'Donovan, Maura Coughlin, Xaviere Lornage, Nicola Foulds, Simon R Hammans, A Reghan Foley, Charlotte M Fare, Alice F Ford, Masashi Ogasawara, Aki Sato, Aritoshi Iida, Pinki Munot, Gautam Ambegaonkar, Rahul Phadke, Dominic G O'Donovan, Rebecca Buchert, Mona Grimmel, Ana Töpf, Irina T Zaharieva, Lauren Brady, Ying Hu, Thomas E Lloyd, Andrea Klein, Maja Steinlin, Alice Kuster, Sandra Mercier, Pascale Marcorelles, Yann Péréon, Emmanuelle Fleurence, Adnan Manzur, Sarah Ennis, Rosanna Upstill-Goddard, Luca Bello, Cinzia Bertolin, Elena Pegoraro, Leonardo Salviati, Courtney E French, Andriy Shatillo, F Lucy Raymond, Tobias B Haack, Susana Quijano-Roy, Johann Böhm, Isabelle Nelson, Tanya Stojkovic, Teresinha Evangelista, Volker Straub, Norma B Romero, Jocelyn Laporte, Francesco Muntoni, Ichizo Nishino, Mark A Tarnopolsky, James Shorter, Carsten G Bönnemann, and J Paul Taylor

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Structural enzymology of cholesterol biosynthesis and storage., Tao Long, Erik W Debler, and Xiaochun Li

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Functions of ADP-ribose transferases in the maintenance of telomere integrity, Daniela Muoio, Natalie Laspata, and Elise Fouquerel

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Evidence for Paracrine Protective Role of Exogenous αA-Crystallin in Retinal Ganglion Cells, Madhu Nath, Zachary B Sluzala, Ashutosh S Phadte, Yang Shan, Angela M Myers, and Patrice E Fort

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Viral Ejection Proteins: Mosaically Conserved, Conformational Gymnasts, Nicholas A. Swanson, Chun-Feng Hou, and Gino Cingolani

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Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes, Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino

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Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes., Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino

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Mechanisms of mitochondrial promoter recognition in humans and other mammalian species, Angelica Zamudio-Ochoa, Yaroslav I Morozov, Azadeh Sarfallah, Michael Anikin, and Dmitry Temiakov

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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis., Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, and Michael Niederweis

Manuscripts from 2021

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Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation., Danique Beijer, Hong Joo Kim, Lin Guo, Kevin O'Donovan, Inès Mademan, Tine Deconinck, Kristof Van Schil, Charlotte M Fare, Lauren E Drake, Alice F Ford, Andrzej Kochański, Dagmara Kabzińska, Nicolas Dubuisson, Peter Van den Bergh, Nicol C Voermans, Richard Jlf Lemmers, Silvère M van der Maarel, Devon Bonner, Jacinda B Sampson, Matthew T Wheeler, Anahit Mehrabyan, Steven Palmer, Peter De Jonghe, James Shorter, J Paul Taylor, and Jonathan Baets

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Historical Perspective of the G Protein-Coupled Receptor Kinase Family., Jeffrey L Benovic

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Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development, Gregory L Branigan, Kelly S Olsen, Isabella Burda, Matthew W Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D D'Antonio, Ian E Briggs, and Angela J DiBenedetto

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A stress-free strategy to correct point mutations in patient iPS cells, Jingli Cai, Elizabeth Kropf, Ya-Ming Hou, and Lorraine Iacovitti

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Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP, Christine E Carbone, Anna B Loveland, Howard Gamper, Ya-Ming Hou, Gabriel Demo, and Andrei A Korostelev

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Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining, Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, and Richard T Pomerantz

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Polθ reverse transcribes RNA and promotes RNA-templated DNA repair, Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, and Richard Pomerantz

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Dna polymerase θ: A cancer drug target with reverse transcriptase activity, Xiaojiang Chen and Richard T. Pomerantz

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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation., Gabriel Demo, Howard Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, and Andrei A. Korostelev

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Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates., Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, and Steven B. McMahon

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Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design., Lukas Friedrich, Gino Cingolani, Ying-Hui Ko, Mariaclara Iaselli, Morena Miciaccia, Maria Grazia Perrone, Konstantin Neukirch, Veronika Bobinger, Daniel Merk, Robert Klaus Hofstetter, Oliver Werz, Andreas Koeberle, Antonio Scilimati, and Gisbert Schneider

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An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference., Miki Fujioka, Anastasiya Nezdyur, and James B. Jaynes

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Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA., Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, and Ya-Ming Hou

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Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms, Jennifer Guerrero-Santoro, Jian Ming Khor, Ayşe Haruka Açıkbaş, James B. Jaynes, and Charles A Ettensohn

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TERA-Seq: true end-to-end sequencing of native RNA molecules for transcriptome characterization, Fadia Ibrahim, Jan Oppelt, Manolis Maragkakis, and Zissimos Mourelatos

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DNA Mismatch Repair and its Role in Huntington's Disease, Ravi R Iyer and Anna Pluciennik

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Targeting oncogenic gαq/11 in uveal melanoma, Dominic Lapadula and Jeffrey L Benovic

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Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, and Jeffrey L Benovic

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Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness, Pratyusha Mandal, Lynsey Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher Dillon, Heather Koehler, Linda Roback, Emad S Alnemri, Douglas Green, and Edward Mocarski

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Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression, Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R. Buskirk, and Ya-Ming Hou

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Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis., Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L.J. Tybulewicz, Teresa Fernandes-Alnemri, and Emad S. Alnemri

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Three-dimensional structure of human cyclooxygenase (hCOX)-1., Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, and Antonio Scilimati

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The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS., Joseph D Orkin, Michael J Montague, Daniela Tejada-Martinez, Marc de Manuel, Javier Del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A Hodgson, Mareike C Janiak, Lukas F K Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H Perry, Carmen Soto Valverde, Jia Tang, Wesley C Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès-Bonet, Roman Krawetz, and Amanda D Melin

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Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders, Luca Pagliaroli, Patrizia Porazzi, Alyxandra T Curtis, Chiara Scopa, Harald M M Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A Welsh, Sarah Offley, Connor A Ott, Bruno Calabretta, Samantha A Brugmann, Gijs W E Santen, and Marco Trizzino

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The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination, Luca Pagliaroli and Marco Trizzino

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Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression., Kalpana Rajanala, Lauren M. Klayman, and Philip B. Wedegaertner

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Expression and purification of phage T7 ejection proteins for cryo-EM analysis, Nicholas A. Swanson, Ravi K Lokareddy, Fenglin Li, Chun-Feng Hou, Mikhail Pavlenok, Michael Niederweis, and Gino Cingolani

Manuscripts from 2020

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Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages., Ardeshir Ariana, Norah A Alturki, Stephanie Hajjar, Deborah J Stumpo, Christopher Tiedje, Emad S Alnemri, Matthias Gaestel, Perry J Blackshear, and Subash Sad

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Purification and Use of tRNA for Enzymatic Post-translational Addition of Amino Acids to Proteins., Irem Avcilar-Kucukgoze, Howard Gamper, Ya-Ming Hou, and Anna Kashina

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Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups, Christine R Fisher, David E Lowe, Todd G Smith, Yong Yang, Christina L Hutson, Christoph Wirblich, Gino Cingolani, and Matthias J. Schnell

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A Label-Free Assay for Aminoacylation of tRNA, Howard Gamper and Ya-Ming Hou

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Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion, Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt

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Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion., Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt

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Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses., Lu Liu, Shuaiyi Chen, Miao Yu, Chenxu Ge, Mengmeng Ren, Boya Liu, Xin Yang, Thomas W Christian, Ya-Ming Hou, Junhua Zou, Wei-Guo Zhu, and Jianyuan Luo

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Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment., Ravi K Lokareddy, Ying Hui Ko, Nathaniel Hong, Steven G Doll, Marcin Paduch, Michael Niederweis, Anthony A Kossiakoff, and Gino Cingolani

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Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation., Marzia Niazi, Tyler J. Florio, Ruoyu Yang, Ravi K. Lokareddy, Nicholas A. Swanson, Richard E. Gillilan, and Gino Cingolani

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Mg2+-Dependent Methyl Transfer by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Study, Agata P Perlinska, Marcin Kalek, Thomas Christian, Ya-Ming Hou, and Joanna I Sulkowska

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Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells, Fabio Quaglia, Shiv Ram Krishn, George G. Daaboul, Srawasti Sarker, Raffaella Pippad, Josep Domingo-Domenech, Gaurav Kumar, Paolo Fortina, Peter McCuee, William K. Kelly, Himisha Beltran, Qin Liu, and Lucia R. Languinoa

Manuscripts from 2019

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Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy., Frederick J. Arnold, Anna Pluciennik, and Diane E. Merry

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Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA., Gino Cingolani, Michael McCauley, Anna Lobley, Alexander J Bryer, Jordan Wesolowski, Deanna L Greco, Ravi K Lokareddy, Erik Ronzone, Juan R Perilla, and Fabienne Paumet

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Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase., Travis Eisemann, Marie-France Langelier, and John M. Pascal

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Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC., Victoria J. Gennaro, Helen Wedegaertner, and Steven B. McMahon

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Codon-Specific Translation by m1G37 Methylation of tRNA, Ya-Ming Hou, Isao Masuda, and Howard Gamper

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Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation, Julia L Jones, Katharina B. Hofmann, Andrew T. Cowan, Dmitry Temiakov, Patrick Cramer, and Michael Anikin

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tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance., Isao Masuda, Ryuma Matsubara, Thomas Christian, Enrique R. Rojas, Srujana S. Yadavalli, Lisheng Zhang, Mark Goulian, Leonard J. Foster, Kerwyn Casey Huang, and Ya-Ming Hou

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Heme and hemoglobin utilization by Mycobacterium tuberculosis., Avishek Mitra, Ying-Hui Ko, Gino Cingolani, and Michael Niederweis

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Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, and Robert W Burgess

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Gasdermins in Apoptosis: New players in an Old Game., Corey Rogers and Emad S. Alnemri

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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation., Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, and Emad S. Alnemri

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Characterization of resistance to a potent D-peptide HIV entry inhibitor., Amanda R Smith, Matthew T Weinstock, Amanda E Siglin, Frank G Whitby, J Nicholas Francis, Christopher P Hill, Debra M Eckert, Michael J Root, and Michael S Kay

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Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes, Chong Sun, Jie Song, Yanjun Jiang, Chongbo Zhao, Jiahong Lu, Yuxin Li, Yin Wang, Mingshi Gao, Jianying Xi, Sushan Luo, Meixia Li, Kevin Donaldson, Stephanie N. Oprescu, Thomas P. Slavin, Sansan Lee, Pilar L. Magoulas, Andrea M. Lewis, Lisa Emrick, Seema R. Lalani, Zhiyv Niu, Megan L. Landsverk, Magdalena Walkiewicz, Richard E. Person, Hui Mei, Jill A. Rosenfeld, Yaping Yang, Anthony Antonellis, Ya-Ming Hou, Jie Lin, and Victor W. Zhang

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A unique role for clathrin light chain A in cell spreading and migration., Oxana M. Tsygankova and James H. Keen

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How to Untie a Protein Knot., Sitao Yin, Brittiny Dhital, and Ya-Ming Hou

Manuscripts from 2018

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Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis., Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, and Subash Sad

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SUMO-mediated regulation of NLRP3 modulates inflammasome activity., Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad S Alnemri, Marcin Drag, Yuan Chen, and Pascal Meier

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Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase, Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C. Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S. Patel, Richard H. Ebright, and Bryce E. Nickels

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Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K, Lan Cheng, Moza Al-Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning, Chris Peers, and Natalia A Riobo-Del Galdo

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tRNA 3'-amino-tailing for stable amino acid attachment., Howard Gamper and Ya-Ming Hou

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Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells., Victoria J. Gennaro, Timothy J. Stanek, Amy R. Peck, Yunguang Sun, Feng Wang, Shuo Qie, Karen E. Knudsen, Hallgeir Rui, Tauseef Butt, J. Alan Diehl, and Steven B. McMahon

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Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio de Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, and Douglas G. Tilley

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Structural basis of mitochondrial transcription., Hauke S. Hillen, Dmitry Temiakov, and Patrick Cramer

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Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia., Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R. Manning, and Natalia A. Riobo-Del Galdo

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Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response., Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, and Laurie K. Read

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In Vitro growth of human ovarian follicles for fertility preservation, Diego Marin, Min Yang, and Tianren Wang

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DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation., Scott J. Morin, Xin Tao, Diego Marin, Yiping Zhan, Jessica Landis, Jenna Bedard, Richard T. Scott, and Emre Seli

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The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, and Edward Winter

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Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy., Kristin N. Parent, Jason R. Schrad, and Gino Cingolani

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The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes., Ian Gaël Rodrigue-Gervais, Karine Doiron, Claudia Champagne, Lindsey Mayes, Gabriel André Leiva-Torres, Paulin Vanié, Todd Douglas, Silvia M. Vidal, Emad S. Alnemri, and Maya Saleh

Manuscripts from 2017

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Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors., Koree W. Ahn and Michael J. Root

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Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers, Angelina A. Akishina, J. E. Vorontsova, Roman O. Cherezov, Ilja B. Mertsalov, Olga G. Zatsepina, Mikhail S. Slezinger, Vladislav M. Panin, Svetlana Petruk, Grigori N. Enikolopov, Alexander M. Mazo, Olga B. Simonova, and Boris A. Kuzin

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The kinetic mechanism of bacterial ribosome recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, and Barry S. Cooperman

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Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, and Andrew E. Aplin

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Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)., Gino Cingolani, Andrea Panella, Maria Grazia Perrone, Paola Vitale, Giuseppe Di Mauro, Cosimo G G. Fortuna, Roger S. Armen, Savina Ferorelli, William L. Smith, and Antonio Scilimati

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The Structure and C=C Vibrational Frequencies of the all- trans Polyenes C2nH2n+2(n=2-15), C2nH2n(Me)2(n=2-13), and C2nH2n(tert-Butyl)2(n=2-5): Computational Results, George R. De Maré, Niny Z. Rao, and Charles W. Block

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Functional selectivity of GPCR-directed drug action through location bias., Roshanak Irannejad, Veronica Pessino, Delphine Mika, Bo Huang, Philip B. Wedegaertner, Marco Conti, and Mark von Zastrow

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Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G., Nobuhiro Iwakura, Takeshi Yokoyama, Fabio Quaglia, Kaoru Mitsuoka, Kazuhiro Mio, Hideki Shigematsu, Mikako Shirouzu, Akira Kaji, and Hideko Kaji

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Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5., Konstantin E. Komolov, Yang Du, Nguyen Minh Duc, Robin M. Betz, João P.G.L.M. Rodrigues, Ryan D. Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M. Adams, Ron O. Dror, Ka Young Chung, Brian K. Kobilka, and Jeffrey L. Benovic

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Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70., Taosui Li, Jacob W Hodgson, Svetlana Petruk, Alexander Mazo, and Hugh W Brock

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Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation., Ravi K. Lokareddy, Rajeshwer S. Sankhala, Ankoor Roy, Pavel V. Afonine, Tina Motwani, Carolyn M M. Teschke, Kristin N. Parent, and Gino Cingolani

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A genetically encoded fluorescent tRNA is active in live-cell protein synthesis., Isao Masuda, Takao Igarashi, Reiko Sakaguchi, Ram G. Nitharwal, Ryuichi Takase, Kyu Young Han, Benjamin J. Leslie, Cuiping Liu, Howard Gamper, Taekjip Ha, Suparna Sanyal, and Ya-Ming Hou

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Detection and molecular status of Isospora sp. from the domestic pigeon (Columba livia domestica)., Ryuma Matsubara, Yasuhiro Fukuda, Fumi Murakoshi, Osamu Nomura, Toru Suzuki, Chika Tada, and Yutaka Nakai

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Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands., Jacob Peacock and James B Jaynes

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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death., Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, and Emad S. Alnemri

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Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1., Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, and Gino Cingolani

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G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans., Jianjun Wang, Jiansong Luo, Dipendra K. Aryal, William C. Wetsel, Richard Nass, and Jeffrey L. Benovic

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Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms., Wei Wu, Rajeshwer S. Sankhala, Tyler J Florio, Lixin Zhou, Nhan L.T. Nguyen, Ravi K. Lokareddy, Gino Cingolani, and Nelly Panté

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The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms., Jill M. Yersak, Heather L. Montie, Erica S. Chevalier-Larsen, Yuhong Liu, Lan Huang, Martin Rechsteiner, and Diane E. Merry

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Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation., Sungsoo M. Yoo, Arash Latifkar, Richard A. Cerione, and Marc A. Antonyak