Manuscripts from 2018
Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis., Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, and Subash Sad
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, and Edward Winter
Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy., Kristin N. Parent, Jason R. Schrad, and Gino Cingolani
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes., Ian Gaël Rodrigue-Gervais, Karine Doiron, Claudia Champagne, Lindsey Mayes, Gabriel André Leiva-Torres, Paulin Vanié, Todd Douglas, Silvia M. Vidal, Emad S. Alnemri, and Maya Saleh
Manuscripts from 2017
Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors., Koree W. Ahn and Michael J. Root
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers, Angelina A. Akishina, J. E. Vorontsova, Roman O. Cherezov, Ilja B. Mertsalov, Olga G. Zatsepina, Mikhail S. Slezinger, Vladislav M. Panin, Svetlana Petruk, Grigori N. Enikolopov, Alexander M. Mazo, Olga B. Simonova, and Boris A. Kuzin
The kinetic mechanism of bacterial ribosome recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, and Barry S. Cooperman
Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, and Andrew E. Aplin
The Structure and C=C Vibrational Frequencies of the all- trans Polyenes C2nH2n+2(n=2-15), C2nH2n(Me)2(n=2-13), and C2nH2n(tert-Butyl)2(n=2-5): Computational Results, George R. De Maré, Niny Z. Rao, and Charles W. Block
Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G., Nobuhiro Iwakura, Takeshi Yokoyama, Fabio Quaglia, Kaoru Mitsuoka, Kazuhiro Mio, Hideki Shigematsu, Mikako Shirouzu, Akira Kaji, and Hideko Kaji
Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5., Konstantin E. Komolov, Yang Du, Nguyen Minh Duc, Robin M. Betz, João P.G.L.M. Rodrigues, Ryan D. Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M. Adams, Ron O. Dror, Ka Young Chung, Brian K. Kobilka, and Jeffrey L. Benovic
Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70., Taosui Li, Jacob W Hodgson, Svetlana Petruk, Alexander Mazo, and Hugh W Brock
Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation., Ravi K. Lokareddy, Rajeshwer S. Sankhala, Ankoor Roy, Pavel V. Afonine, Tina Motwani, Carolyn M M. Teschke, Kristin N. Parent, and Gino Cingolani
A genetically encoded fluorescent tRNA is active in live-cell protein synthesis., Isao Masuda, Takao Igarashi, Reiko Sakaguchi, Ram G. Nitharwal, Ryuichi Takase, Kyu Young Han, Benjamin J. Leslie, Cuiping Liu, Howard Gamper, Taekjip Ha, Suparna Sanyal, and Ya-Ming Hou
Detection and molecular status of Isospora sp. from the domestic pigeon (Columba livia domestica)., Ryuma Matsubara, Yasuhiro Fukuda, Fumi Murakoshi, Osamu Nomura, Toru Suzuki, Chika Tada, and Yutaka Nakai
Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands., Jacob Peacock and James B Jaynes
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death., Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, and Emad S. Alnemri
Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1., Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, and Gino Cingolani
G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans., Jianjun Wang, Jiansong Luo, Dipendra K. Aryal, William C. Wetsel, Richard Nass, and Jeffrey L. Benovic
Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms., Wei Wu, Rajeshwer S. Sankhala, Tyler J Florio, Lixin Zhou, Nhan L.T. Nguyen, Ravi K. Lokareddy, Gino Cingolani, and Nelly Panté
The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms., Jill M. Yersak, Heather L. Montie, Erica S. Chevalier-Larsen, Yuhong Liu, Lan Huang, Martin Rechsteiner, and Diane E. Merry
Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation., Sungsoo M. Yoo, Arash Latifkar, Richard A. Cerione, and Marc A. Antonyak
Manuscripts from 2016
Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria., David H. Ardell and Ya-Ming Hou
Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans., Miki Fujioka, Hemlata Mistry, Paul Schedl, and James B. Jaynes
Chromatin proteins and RNA are associated with DNA during all phases of mitosis., Kathryn L Black, Svetlana Petruk, Tyler K Fenstermaker, Jacob W Hodgson, Jeffrey L Caplan, Hugh W Brock, and Alexander Mazo
Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus., George J. Leslie, Jianbin Wang, Max W. Richardson, Beth S. Haggarty, Kevin L. Hua, Jennifer Duong, Anthony J. Secreto, Andrea P.O. Jordon, Josephine Romano, Kritika E. Kumar, Joshua J. DeClercq, Philip D. Gregory, Carl H. June, Michael J. Root, James L. Riley, Michael C. Holmes, and James A. Hoxie
Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction., Cuiping Liu, Aaron J Stonestrom, Thomas Christian, Jeongsik Yong, Ryuichi Takase, Ya-Ming Hou, and Xiaolu Yang
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation., Dmitry Ratner, M Pontus A Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, and Egil Lien
PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage., Amanda A Riccio, Gino Cingolani, and John M Pascal
The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins., Jessica H Shinn-Thomas, Jacob J Del Campo, Jianjun Wang, and William A Mohler
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor., Xufan Tian, Roshanak Irannejad, Shanna L. Bowman, Yang Du, Manojkumar A. Puthenveedu, Mark von Zastrow, and Jeffrey L. Benovic
A PARP1-ERK2 synergism is required for the induction of LTP., L Visochek, G Grigoryan, A Kalal, H Milshtein-Parush, N Gazit, I Slutsky, A Yeheskel, A Shainberg, A Castiel, R Seger, Marie-France Langelier, F Dantzer, Pascal Jabbour MD, M Segal, and M Cohen-Armon
Manuscripts from 2015
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, and M G Mahoney
Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease., Jason P Chua, Satya L Reddy, Zhigang Yu, Elisa Giorgetti, Heather L Montie, Sarmistha Mukherjee, Jake Higgins, Richard C McEachin, Diane M Robins, Diane E Merry, Jorge A Iñiguez-Lluhí, and Andrew P Lieberman
Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy., Ya-Ming Hou, , and Wei Yang
Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity., Yuan-Yuan Jin, Jade Andrade, and Eric Wickstrom
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3., Seokwon Kang, Teresa Fernandes-Alnemri, Corey Rogers, Lindsey Mayes, Ying Wang, Christopher Dillon, Linda Roback, William Kaiser, Andrew Oberst, Junji Sagara, Katherine A Fitzgerald, Douglas R Green, Jianke Zhang, Edward S Mocarski, and Emad S Alnemri
Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases, Konstantin E. Komolov, Anshul Bhardwaj, and Jeffrey L. Benovic
Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G., Takahide Kouno, Elizabeth M Luengas, Megumi Shigematsu, Shivender M D Shandilya, JingYing Zhang, Luan Chen, Mayuko Hara, Celia A Schiffer, Reuben S Harris, and Hiroshi Matsuo
Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins., Annemarie Kralt, Noorjahan B Jagalur, Vincent van den Boom, Ravi K Lokareddy, Anton Steen, Gino Cingolani, Maarten Fornerod, and Liesbeth M Veenhoff
G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway., S Malik, R G deRubio, M Trembley, R Irannejad, Philip B Wedegaertner, and A V Smrcka
The rise and fall of poly(ADP-ribose): An enzymatic perspective., John M. Pascal and Tom Ellenberger
Diversification of importin-α isoforms in cellular trafficking and disease states., Ruth A. Pumroy and Gino Cingolani
The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD., Jim Sun, Axel Siroy, Ravi K Lokareddy, Alexander Speer, Kathryn S Doornbos, Gino Cingolani, and Michael Niederweis
Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast., Chong Wai Tio, Gregory Omerza, Sham Sunder, and Edward Winter
Manuscripts from 2014
Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin., Dimitra Aggeli, Erik Kish-Trier, Meng Chi Lin, Brian Haarer, Gino Cingolani, John A Cooper, Stephan Wilkens, and David C Amberg
Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography., Anshul Bhardwaj, Sherwood R Casjens, and Gino Cingolani
Architecture of viral genome-delivery molecular machines., Anshul Bhardwaj, Adam S. Olia, and Gino Cingolani
Multisite Phosphorylation of the Sum1 Transcriptional Repressor by S-Phase Kinases Controls Exit from Meiotic Prophase in Yeast., Daniel Corbi, Sham Sunder, Michael Weinreich, Aikaterini Skokotas, Erica S Johnson, and Edward Winter
Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations., Laurie B Griffin, Reiko Sakaguchi, David McGuigan, Michael A Gonzalez, Charles Searby, Stephan Züchner, Ya-Ming Hou, and Anthony Antonellis
PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1., Marie-France Langelier, Amanda A Riccio, and John M Pascal
The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain., Kim G Lieu, Eun-Hee Shim, Jinling Wang, Ravi K Lokareddy, Tao Tao, Gino Cingolani, Gerard P Zambetti, and David A Jans
Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA., Jacob R Peacock, Ryan R Walvoord, Angela Y Chang, Marisa C Kozlowski, , and Ya-Ming Hou
Oligomerization, Conformational Stability and Thermal Unfolding of Harpin, HrpZPss and Its Hypersensitive Response-Inducing C-Terminal Fragment, C-214-HrpZPss., Pradip K Tarafdar, Lakshmi Vasudev Vedantam, Rajeshwer S Sankhala, Pallinti Purushotham, Appa Rao Podile, and Musti J Swamy
Monitoring Cancer Therapy by mRNA PET Imaging, Eric Wickstrom
The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function., Hua Xu, Xiaoshan Jiang, Ke Shen, Christopher C. Fischer, and Philip B Wedegaertner
Manuscripts from 2013
Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, and Montserrat Corominas
Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor., Ying-Ju Chen, Sue Oldfield, Adrian J. Butcher, Andrew B. Tobin, Kunal Saxena, Vsevolod V. Gurevich, Jeffrey L. Benovic, Graeme Henderson, and Eamonn Kelly
Conservation of structure and mechanism by Trm5 enzymes., Thomas Christian, Howard Gamper, and Ya-Ming Hou
The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading., Miki Fujioka, Guizhi Sun, and James B Jaynes
Regulation of cell death by transfer RNA., Ya-Ming Hou and Xiaolu Yang
Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors., Shinya Kurata, Ben Shen, Jun O Liu, Nono Takeuchi, Akira Kaji, and Hideko Kaji
The tip of the tail needle affects the rate of DNA delivery by bacteriophage P22., Justin C Leavitt, Lasha Gogokhia, Eddie B Gilcrease, Anshul Bhardwaj, Gino Cingolani, and Sherwood R Casjens
Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, and Jouni Uitto
Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission., Matthew K Martz, Elda Grabocka, Neil Beeharry, Timothy J Yen, and Philip B Wedegaertner
Molecular determinants of epidermal growth factor binding: a molecular dynamics study., Jeffrey M Sanders, Matthew E Wampole, Mathew L. Thakur, and Eric Wickstrom
Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling., Takeshi Sasamura, Kenji Matsuno, and Mark E Fortini
Dynein and dynactin leverage their bivalent character to form a high-affinity interaction., Amanda E Siglin, Shangjin Sun, Jeffrey K Moore, Sarah Tan, Martin Poenie, James D Lear, Tatyana Polenova, John A Cooper, and John C Williams
G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation., Christopher H So, Allison Michal, Konstantin E Komolov, Jiansong Luo, and Jeffrey L Benovic
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation., Tharan Srikumar, Megan C Lewicki, Michael Costanzo, Johnny M Tkach, Harm van Bakel, Kyle Tsui, Erica S Johnson, Grant W Brown, Brenda J Andrews, Charles Boone, Guri Giaever, Corey Nislow, and Brian Raught
Structural Implications for Selective Targeting of PARPs., Jamin D Steffen, MD; Jonathan Brody, MD; Roger S Armen, MD; and John M Pascal, MD
Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass., Matthew E Wampole, John C Kairys, Edith P Mitchell, Martha L Ankeny, Mathew L Thakur, and Eric Wickstrom
Manuscripts from 2012
Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy., Erica S Chevalier-Larsen and Diane E Merry
Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels., Milana Frenkel-Morgenstern, Tamar Danon, Thomas Christian, Takao Igarashi, Lydia Cohen, Ya-Ming Hou, and Lars Juhl Jensen
Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired., Miki Fujioka, Brian Gebelein, Zenobia C Cofer, Richard S Mann, and James B Jaynes
Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers., Miki Fujioka and James B Jaynes
Synergetic effect of recoverin and calmodulin on regulation of rhodopsin kinase., Ilya I Grigoriev, Ivan I Senin, Natalya K Tikhomirova, Konstantin E Komolov, Sergei E Permyakov, Evgeni Yu Zernii, Karl-Wilhelm Koch, and Pavel P Philippov
Global cellular regulation including cardiac function by post-translational protein arginylation., Hideko Kaji and Akira Kaji
Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors., Shinya Kurata, Ben Shen, Jun O Liu, Nono Takeuchi, Akira Kaji, and Hideko Kaji
Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria., Naresh Babu V Sepuri, Madhavi Gorla, and Michael P King
Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria., Naresh Babu V Sepuri, Madhavi Gorla, and Michael P King
Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons., Serafín Vivanco-Domínguez, José Bueno-Martínez, Gloria León-Avila, Nobuhiro Iwakura, Akira Kaji, Hideko Kaji, and Gabriel Guarneros
Structural insights into initial and intermediate steps of the ribosome-recycling process, Takeshi Yokoyama, Tanvir R. Shaikh, Nobuhiro Iwakura, Hideko Kaji, Akira Kaji, and Rajendra K. Agrawal
Manuscripts from 2011
Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an autoinhibited conformation., Gino Cingolani and Thomas M Duncan
Protein modification by arginylation, Hideko Kaji and Akira Kaji
Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding., Cuiping Liu, Howard Gamper, Hanqing Liu, Barry S Cooperman, and Ya-Ming Hou
Three-dimensional structure of a viral genome-delivery portal vertex., Adam S Olia, Peter E Prevelige, John E Johnson, and Gino Cingolani
Three Dimensional Projection Environment for Molecular Design and Surgical Simulation, Matthew Wampole, Eric Wickstrom, Chang-Po Chen, Devakumar Devadhas, Yuan-Yuan Jin, Jeffrey M. Sanders, John C. Kairys, Martha L. Ankeny, Rui Hu, Kenneth E. Barner, Karl V. Steiner, and Mathew L. Thakur
Mitochondrial genome sequence analysis: a custom bioinformatics pipeline substantially improves Affymetrix MitoChip v2.0 call rate and accuracy., Hongbo M Xie, Juan C Perin, Theodore G Schurr, Matthew C Dulik, Sergey I Zhadanov, Joseph A Baur, Michael P King, Emily Place, Colleen Clarke, Michael Grauer, Jonathan Schug, Avni Santani, Anthony Albano, Cecilia Kim, Vincent Procaccio, Hakon Hakonarson, Xiaowu Gai, and Marni J Falk
Manuscripts from 2010
Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates., Chang-Po Chen and Eric Wickstrom
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5., Thomas Christian, Georges Lahoud, Cuiping Liu, Katherine Hoffmann, John J Perona, and Ya-Ming Hou
Control of catalytic cycle by a pair of analogous tRNA modification enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, and Ya-Ming Hou
Control of catalytic cycle by a pair of analogous tRNA modification enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, and Ya-Ming Hou
Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP., Shinya Kurata, Klaus H Nielsen, Sarah F Mitchell, Jon R Lorsch, Akira Kaji, and Hideko Kaji
Biosynthesis: A new (old) way of hijacking tRNA., Georges Lahoud and Ya-Ming Hou
Phosphorylation meets nuclear import: a review., Jonathan D Nardozzi, Kaylen Lott, and Gino Cingolani
Manuscripts from 2009
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA., Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu, and Emad S Alnemri
Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, and Koichi Iijima
Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, and Koichi Iijima
Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila., Koichi Iijima, LiJuan Zhao, Christopher Shenton, and Kanae Iijima-Ando