Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide tmax (P < 0.001), Cmax (P < 0.05), and mean residence time (P < 0.0001). Area under the insulin concentration curve (AUC0–300) declined by ∼24% from days 0 to 7 (P < 0.05). These results confirm/extend previous observations showing progressive acceleration of insulin exposure over IIS wear time. This may have implications for PWD and designers of closed-loop algorithms, although larger studies are necessary to confirm this. The study was registered in clinicaltrials.gov (NCT04398030).
Kastner, Jasmin R.; Bailey, Timothy S.; Strange, Poul; Shi, Leon; Oberg, Keith A.; Strasma, Paul J.; Joseph, Jeffrey I.; and Muchmore, Douglas B., "Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear" (2022). Department of Anesthesiology Faculty Papers. Paper 86.
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This article is the author's final published version in Diabetes Technology and Therapeutics, Volume 25, Issue 2, 2023, Pg. 143 - 147.
The published version is available at https://doi.org/10.1089/dia.2022.0323. Copyright © Jasmin R. Kastner, et al., 2023; Published by Mary Ann Liebert, Inc.