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This article is the author’s final published version in Journal of Community Hospital Internal Medicine Perspectives, Volume 10, Issue 2, May 2020, Pages 133-137.

The published version is available at Copyright © Ullah et al.

Publication made possible in part by support from the Thomas Jefferson University + Philadelphia University Open Access Fund


Neuroleptic malignant syndrome is a potentially fatal neurological condition secondary toantipsychotic medication. It is characterized by distinctive clinical findings and autonomicdisturbances. NMS has not been associated with Takotsubo cardiomyopathy (TCM).

TCM is an abnormal response to physiological stressors resulting from the autonomicabnormalities which at times can mimic myocardial infarction (MI). We present a unique caseof a 54-year-old female with bipolar disease presenting with lithium and haloperidol-inducedNMS complicated by TCM. The purpose of this case is to make clinicians aware of this rareassociation.

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