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This article has been peer reviewed. It is the authors' final version prior to publication in Handbook of Experimental Pharmacology

Volume 240, February 2017

The published version is available at DOI: 10.1007/164_2017_1 Copyright © Springer International Publishing Switzerland


Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex.

Available for download on Wednesday, February 14, 2018