Dose equivalency of metoprolol and carvedilol for beta-
1 blockade remains subject of ongoing debate. The
degree of beta-1 blockade is best assessed in vivo by
blunting of the exercise induced heart rate. Accordingly,
we examined baseline and peak exercise heart rate in
subjects with chronic heart failure (CHF) treated with
carvedilol or metoprolol. To correct for possible
differences in norepinephrine (NE) release due to beta-2
blockade, we also measured NE levels at baseline and
Vittorio, Timothy J.; Onat, Duygu; Colombo, Paolo C.; Stathopoulos, John; Sulejman, Cselaj; Rose, Andrew B.; Miller, Gillian; Trufant, Joshua; Goldsmith, Rochelle; and Jorde, Ulrich P.
"Effect Of Endogenous Noradenaline Release On Peak Exercise Heart Rate In Subjects With Chronic Heart Failure Receiving Carvedilol Versus Metoprolol,"
The Medicine Forum:
Vol. 6, Article 17.
Available at: http://jdc.jefferson.edu/tmf/vol6/iss1/17