https://doi.org/10.29046/TMF.006.1.003">
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Abstract

Background

Dose equivalency of metoprolol and carvedilol for beta-

1 blockade remains subject of ongoing debate. The

degree of beta-1 blockade is best assessed in vivo by

blunting of the exercise induced heart rate. Accordingly,

we examined baseline and peak exercise heart rate in

subjects with chronic heart failure (CHF) treated with

carvedilol or metoprolol. To correct for possible

differences in norepinephrine (NE) release due to beta-2

blockade, we also measured NE levels at baseline and

peak exercise.

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https://doi.org/10.29046/TMF.006.1.003">