Amiodarone is a common drug used to treat arrhythmias and its side effects are diverse. An important adverse effect is amiodarone-induced thyrotoxicosis (AIT), which can potentially lead to a pro-arrythmogenic state. There have been limited studies on the pathogenesis of how thyrotoxicosis increases the risk of ventricular arrhythmias, which causes providers to face a therapeutic challenge in patients who require this medication for the prevention of life threatening arrhythmias. This case report will present a patient with a left ventricular assist device (LVAD) who had recurrent ventricular arrhythmias on chronic amiodarone therapy in the setting of AIT.
Shah, MD, Ashish
"Amiodarone-Induced Thyrotoxicosis and Ventricular Arrhythmias: Case Report and Review of the Literature,"
The Medicine Forum:
Vol. 17, Article 13.
Available at: http://jdc.jefferson.edu/tmf/vol17/iss1/13