Document Type

Article

Publication Date

11-25-2014

Comments

This article has been peer reviewed. It was published in: Oncoscience.

Volume 1, Issue 12, 2014, Pages 765-776.

The published version is available at PMID: 25621293

Copyright © 2014 Zhou and Rigoutsos

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D. As the name implies, their expression is induced by retinoic acid but beyond that very little is known about their function. In recent years, one member, GPRC5A, has been receiving increasing attention as it was shown to play important roles in human cancers. As a matter of fact, dysregulation of GPRC5A has been associated with several cancers including lung cancer, breast cancer, colorectal cancer, and pancreatic cancer. Here we review the current state of knowledge about the heterogeneity and evolution of GPRC5A, its regulation, its molecular functions, and its involvement in human disease.

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Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

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