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Theses/Dissertations from 2012

Cyclophilin a, dynein light chain 3, and HIV-1 capsid: defining elements of host-pathogen interactions and roles in viral replication, Angela Conde

Determining the role of toll-like receptors in innate and adaptive immune responses to borrelia hermsii and other antigenic targets of T cell-independent humoral immunity, Gregory S. Dickinson

Adaptation to ethanol dysregulates hepatic miRNA expression and alters the dynamic response of miRNAs during liver regeneration, Rachael P. Dippold

Harnessing the power of recombinant rabies viruses to make safer vaccines and study viral clearance from the brain, Emily A. Gomme

Protection of dopaminergic cells from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-methyl-4-phenylpyridinium toxicity by histone deacetylase inhibitors, Sarah K. Kidd

Nuclear and mitochondrial regulation of cellular differentiation: roles of serum response factor and tumor supressor p53, Nafeesa Hadiyah Hunt Owens

Nonclassical antigen processing and the implications for autoimmunity and infection, Tara M. Robinson

Gene-environment interactions and novel therapeutic interventions in prostate cancer, Supriya Shah

Theses/Dissertations from 2011

The impact of RB deficiency on hepatocyte biology and tumorigenesis, Ryan J. Bourgo

Arsenic-induced cell transformation and angiogenesis requires NADPH oxidase isoform 2-derived reactive oxygen species, Richard L. Carpenter

Prostaglandin D2 differentially regulates functions of human NK cell subsets through distinct receptors, Yingying Chen

MHC Class II restricted processing of endogenous antigens during viral infection, Joseph D. Comber

Therapeutic CDK46 inhibition in breast cancer and the importance of reestablishing cell cycle control through RB activation, Jeffry L. Dean

The effects of expression of thermolabile R789C and R992C collagen II mutants on cell behavior and extracellular matrix structure and function, Deborah Anne Jensen

A comparative analysis of human T cell responses to adenoviral early and late proteins, Amita Joshi

Antibiotic modification of nature's grafts: improving upon nature's scaffolds, Constantinos Ketonis

Characterization of a rat model of chronic headache, Christina R. Maxwell

Mechanisms of RETPTC 3-induced pro-inflammatory signaling, Robert John Neely

Gene expression studies of the VTA in an animal model of Parkinson's disease and the emergence of gremlin as a dopaminergic neuroprotective factor, Sudarshan Phani

Mechanisms of memory CD8+ T cell protection from an acuute lethal viral disease, Sanda S. Remakus

Insertional mutagenesis as a toll for identifying and characterizing novel candidate cancer genes, Jacquelyn Jinan Roth

Elucidation of MHC class II-restricted antigen processing pathways using influnenza epitopes, James S. Testa

Understanding the many facets of RETPTC oncogene activity in thyroid carcinoma: transformation, inflammation, and antigenicity, Josephine Fox Wixted

The 11S proteasomal activator REGy impacts polyglutamine-expanded androgen receptor aggregation and toxicity in cell models of spinal and bulbar muscular atrophy, Jill M. Yersak

Theses/Dissertations from 2010

Analysis of B1b lymphocyte-mediated protective immunity, Matthew J. Colombo

A comprehensive analysis of interferon-beta's role in shaping the immunogenicity and pathogenicity of rabies virus:development of a novel vaccine vector, Elizabeth J. Faul

Multifunctional roles of lactate transporters in wound healing and metastasis, Shannon Gallagher-Colombo

Exploring p53 protein-proetin interactions as targets for chemotherapy, Soyoung Heo

N-Cadherin junction formation drives lens fiber cell differentiation and morphogenesis, Michelle Leonard

Double trouble: How simultaneous immune challenges can result in CNS disease, Christine Matullo

The use of adult adipose-derived stem cells in the creation of a tissue engineered vascular bypass graft, Stephen Edward McIlhenny

Caveolin-1 in human disease:the roles of Caveolin-1 in cancer and atherosclerosis, Stephanos Pavlides

Regulation of apoptosis by p53 and the Ecdysone receptor co-activator TRR in Drosophila, Kristen Marie Riley

Analysis of the function of FADD in hematopoietic stem cells, lineage development and hematopoietic function, Stephen M. Rosenberg

Stat5 transcription factors in human breast cancer:prognosis, tamoxifen response prediction and gene regulation, Amy Ryder

Regulation of meiotic development in Saccharomyces cerevisiae by the meiosis-specific Ime2 protein kinase, Marcus Shin

Biophysical and in vivo characterization of the dynein-dynactin interaction;implications for multiple modes of regulation, Amanda E. Siglin

Type I collagen-integrin interactions in angiogenesis, Kevin Turner

An intestinal prouroguanylin-hypothalamic GUCY2C axis mediates nutrient-induced satiety, Michael A. Valentino

A role for Myb in BCR-ABL(p190)-induced leukemogenesis:regulation of Arf suppression through transcriptional activation of BMI1, Todd J. Waldron

S100A1 competes with calmodulin for calmodulin binding proteins, CAV1.2 and SK2 channels, Kristen Metzler Wilson

Deletion of GSK-3B in vivo: revealing the role of this signal integrator in cardiomyocyte hypertrophy and proliferation, Kathleen Camille Woulfe

Guanylyl cyclase C remodels metastatic architecture through vasodilator-stimulated phosphoprotein, David S. Zuzga

Theses/Dissertations from 2009

Regulation of middle meiotic gene expression by the Sum1 repressor, Noreen T. Ahmed

Influence of opioid and estrogen systems on cocaine withdrawal in females, Lisa M. Ambrose-Lanci

Novel insights into arrestin mediated receptor trafficking, Ronald C. Kern

Regulation of the transcriptional repressor Sum1 by the meiosis-specific kinase Ime2 in Saccharomyces cerevisiae, Michael Moore

Molecular basis of aneuploidy:functions of the aurora kinases, Rad51c, and CREB binding protein in female meiosis, Kristy Shuda

Induction of the osteocytic phenotype:the influence of oxygen on bone cell maturation and survival, Adam M. Zahm

Perlecan coordinates developmental angiogenesis, Jason Joseph Zoeller

Theses/Dissertations from 2008

Approaches toward the investigation of T cell specificities and antigenic determinants in an MHC-matched mouse GVHD model, Michael Jay Appel

T cell-mediated cytotoxicity: understanding the mechanism of effective delivery of a poison pill, Allison M. Beal

In vivo analysis of cell-autonomous versus non-cell-autonomous contributions to neuronal dysfunction in disorders of the basal ganglia, Timothy B. Brown

Structure, folding and engineering of 5-Helix, a designed HIV-1 entry inhibitor, Kelly Champagne

Role of a polybasic motif in plasma membrane targeting and signaling of G-protein alpha subunits, Marykate Crouthamel

Investigating the role of the adenylyl cyclase inhibitory G protein alpha subunit (G-alpha-i2) in dysfunctional myocardium, Brent Robert DeGeorge

A novel integral voltage sensor-interacting protein:shedding light on the gating mechanisms of somatodendritic Kv channels, Kevin Joseph Dougherty

A new mechanism for transcriptional regulation by nuclear hormone receptors during Drosophila development, Danika M. Johnston

Uncovering G protein-coupled receptor kinase-5 as a novel histone deacetylase kinase, Jeffrey S. Martini

Pathogenicity determinants of rabies virus and their function in the pathogenesis of rabies, Rojjanaporn Poumanausahakul

Expression of Kv4 channels in dorsal root ganglion neurons:major determinants of the A-type potassium current, Thanawath Ratanadilok Na Phuket

Immune evasion by silver-haired bat rabies virus and implications for treatment, Anirban Roy

Targeting adrenergic receptors in the treatment of cocaine withdrawal-related anxiety, Carla Ann Rudoy

Theses/Dissertations from 2007

Upregulation of fetal hemoglobin in adult-derived erythroid progenitors, Bubu Ama Banini

Analysis of the molecular mechanisms underlying genomic maintenance in the malaria parasite Plasmodium Falciparum, Jeffrey S. Buguliskis

Insulin receptor substrate 1, a novel oncogene target in breast cancer, Gregory V. Cesarone

RGS-RhoGEFs: interactions with G proteins and identification of novel subcellular locations and functions, Elda Grabocka

IgH chain rearrangement in anti-DNA transgenic B cells, Kerstin Kiefer

Guanylyl cyclase C controls intestinal homeostatis and suppresses intestinal tumorigenesis, Peng Li

B lymphocyte adaptive tolerance: a learned ignorance pathway, Xiaohe Liu

Neutrophils and macrophages in the immune response to parasitic helminths, Amy O'Connell

Molecular physiology of voltage-gated sodium channels: a cation-PI interaction and voltage sensor movement, Vincent P. Santarelli

Micro RNA targeting of IRS-1 and its potential application in inhibition of IRS1-mediated cancer cell proliferation., Bin J. Shi

Guanylyl Cyclase C is a novel immunotherapeutic target for metastatic colorectal cancer, Adam E. Snook

The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription, Gene S. Tan

Hypoxia inducible factor and prolyl hydrolase regulation of growth rate function, Shawn Patrick Terkhorn

Theses/Dissertations from 2006

Molecular characterization of adult human mesenchymal stem cell differentiation: the role of WNT signaling, Genevieve Marie Boland

Functions of the structure-specific metallonuclease flap endonuclease-1 in the Plasmodium falciparum DNA base excision repair pathway, Louis John Casta III

Expression and interactions of hMLH3 in DNA repair: , Nicole Rene Charbonneau

Analysis of T cell receptor alpha chain restriction during a CD4+ V-beta 11+ T cell against minor histocompatability antigens, Christine Gabriella DiRienzo

The function of C R E B - binding protein in germline development, Aaron Matthew Elliot

The CLCA family of calcium-activated chloride, Stella R. Evans

The oxemic environment of the nucleas pulposus and its mechanism of regulation, Deanna Candace Lee

Arrestin-2: structure and function, Shawn K. Milano

Mechanism of G protein-coupled receptor kinase binding and activation by G protein-coupled receptors, Christina S. Pao

Rabies virus as an immunostimulatory carrier molecule for vaccination against anthrax, Mary Ellen Smith

Kinetic restriction of HIV-1 entry inhibition, H Kirby Steger

An essential role for caspase-3 in osteoclast differentiation, Krystyna Helena Szymczyk

Survival and apoptotic-related signaling pathways regulate lens cell differentiation, Gregory F. Weber

Design, synthesis and analysis of ligands for guanylyl cyclase C, R Henry Wolfe

Theses/Dissertations from 2005

Modulation of glucocorticoid-induced apoptosis in acute lymphoblastic leukemia cells, Marc T. Abrams

The interactions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and age with ganglioside therapy on the nigrostriatal dopamine system, David William Anderson

Bone cell survival in microgravity: the effects of vector-averaged gravity on the osteoblast, Michael A. Bucaro

Molecular-genetic analysis of the role of the RSC chromatin remodeling complex during sporulation in Saccharomyces cerevisiae, David Bungard

Androgen modulation alters phenotype and cellular pathology in a mouse model of spinal and bulbar muscular atrophy, Erica S. Chevalier-Larson

Regulation of CD4+ T cell responses to the hepatitus B core antigen, Jessica A. Chichester

Perturbation of oncogenic orthologs in zebrafish, Kevin T. Duffy

Myosin crossbridge kinetics and the mechanism of catch: single turnover of myosin-bound ADP in catch muscle, Aaron S. Franke

Guanylyl cyclase C activity inhibits colorectal carcinoma cell metastatic seeding of the lung by a matrix metalloproteinase-9-dependent mechanism, Wilhelm Johannes Lubbe

Analyses of FHIT Function in tumor suppression, cell cycle progression and DNA damage response, Kelly A. McCorkell