Document Type


Publication Date

April 2008


This article has been peer reviewed. It is the authors' final version prior to publication in Seminars in Oncology 35(2):160-171, April 2008. The published version is available at, copyright © Elsevier, Inc.


Isolated metastases to the pancreas and spleen are a rare occurrence. When they are diagnosed, pancreatic metastases are most often from renal cell carcinoma, lung cancer, and breast cancer. The most common source of splenic metastases is gynecological in origin; the overwhelming majority is ovarian. If extensive staging studies reveal these metastases to be isolated, then curative resection may be warranted. This review will demonstrate that long-term survival may be achieved in patients with isolated metastases and a prolonged disease-free interval.

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