Summer Training Program in Cancer Immunotherapy Copyright (c) 2013 Thomas Jefferson University All rights reserved. http://jdc.jefferson.edu/summercancerimmunotherapy Recent documents in Summer Training Program in Cancer Immunotherapy en-us Sat, 15 Jun 2013 01:31:13 PDT 3600 Creating a model antigen system to test the mechanism of GCC-specific tolerance http://jdc.jefferson.edu/summercancerimmunotherapy/4 http://jdc.jefferson.edu/summercancerimmunotherapy/4 Thu, 13 Jun 2013 08:22:25 PDT Immunotherapeutics for colorectal cancer have been under investigation for decades. Unfortunately, a recent meta-analysis has revealed only a 1% response rate for all immunotherapeutic trials in colorectal cancer, highlighting the need for improved immunotherapeutic target antigens which are tumor-specific, immunogenic, and shared by patients. However, to produce immunological responses targeting tumor/self antigens, one has to overcome tolerance, which has constituted an obstacle to previous studies. Guanylyl cylcase C is the index cancer-mucosa antigen, an emerging class of tumor antigens in colorectal cancer. As a mucosa-restricted antigen, GCC is amenable to immunological targeting and uniquely suited for immunotherapy of colorectal cancers. GCC is only expressed in the intestine and it is so highly restricted in its expression that it can be utilized to detect metastases in non-intestinal tissues. However, previous studies have defined tolerance as a key mechanism limiting efficacy of GCC-targeted vaccines. A tissue-specific model-self antigen expressed in the intestine is required to define tolerance mechanisms to intestinal antigens. Here, we created a model self-antigen comprised of the OT-II CD4+ T cell epitope, OT-I CD8+ T cell epitope, and HA tag B cell epitope that can be employed to create transgenic mice for studying mechanisms of GCC-specific tolerance.

22 PowerPoint slides.

]]> Patrick Ihejirika Colon Cancer Vaccine Study: Development of a Decision Support Intervention for Study Recruitment http://jdc.jefferson.edu/summercancerimmunotherapy/3 http://jdc.jefferson.edu/summercancerimmunotherapy/3 Wed, 30 Jan 2013 12:11:23 PST Focus: Identify factors that may influence trial participation.

28 PowerPoint slides

]]> Evelyn Stevens Colorectal Cancer (CRC) Vaccine Study: Aim 2 Internship Experience http://jdc.jefferson.edu/summercancerimmunotherapy/2 http://jdc.jefferson.edu/summercancerimmunotherapy/2 Wed, 30 Jan 2013 12:07:01 PST Activities:

1. Conducted literature review

2. CRC vaccine study booklet and survey

3. Recruitment survey questionnaire

4. Prepare web-based decision counseling program

38 PowerPoint Slides.

]]> Selasie Goka Colorectal Cancer Vaccine Clinical Trial: Internship Experience in Population Science http://jdc.jefferson.edu/summercancerimmunotherapy/1 http://jdc.jefferson.edu/summercancerimmunotherapy/1 Wed, 30 Jan 2013 12:01:00 PST Internship objectives:

1. Review the literature to identify factors that are likely to influence clinical trail participation.

2. Pretest vaccine trail scenario.

3. Conduct mock decision counseling session.

34 PowerPoint slides

]]> Shannel Ross et al.