Document Type
Article
Publication Date
4-1-2020
Abstract
Objective: To evaluate the correlation between interleukin 10 (IL-10) -1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.
Methods: The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.
Results: In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 -1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80-0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80-0.99), in population-based case-control studies (OR = 0.87, 95% CI = 0.78-0.96), and in studies with ≥500 subjects (OR = 0.88, 95% CI = 0.79-0.99) under the recessive model (AA + AG vs. GG). No associations were found in Asian populations.
Conclusions: The IL10 -1082A/G polymorphism is associated with an increased risk of breast cancer. The association between IL10 -1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.
Recommended Citation
Zhu, ZiYin; Liu, Ji-Bin; Liu, Xi; and Qian, LinXue, "Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis." (2020). Department of Radiology Faculty Papers. Paper 86.
https://jdc.jefferson.edu/radiologyfp/86
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
32349574
Language
English
Comments
This is the final version of the article from the Journal of International Medical Research, Volume 48, Issue 4, 2020, Pages 1-14
The final published version can be found at https://doi.org/10.1177/0300060520904863
Copyright Zhu et. al.