Document Type
Presentation
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Publication Date
2-27-2013
Abstract
Objectives:
1. Will cover the role of TGF-b signaling in cancer and fibrosis
2. Current strategies of targeting TGF-b signaling and their drawbacks
3. Some potential new strategies that we are testing
Presentation: 48 minutes
Recommended Citation
Keshamouni, PhD, Venkateshwar G., "Strategies for Targeting TGF-b signaling for cancer and fibrosis" (2013). Division of Pulmonary and Critical Care Medicine Presentations and Grand Rounds. Presentation 78.
https://jdc.jefferson.edu/pulmcritcaregrandrounds/78
COinS
Comments
Interactions between cancer cells and tumor associated host immune cells initiate and maintain tumor immune tolerance which eventually predominates and mitigates the effective host immune response. The nature of the interactions between cancer cells and immune cells, and the molecular mechanisms underlying tumor immune tolerance is poorly understood. As part of its tumor promoting effects, TFG-b has a broad influence on the immune system through cross-talk with several immunomodulatory signaling pathways including toll-like receptors (TLRs) signaling. TLRs recognize non-self pathogen associated molecular patterns to trigger innate immuric responses. In addition, TLRs can also recognize several endogenous danger associated molecules including heat shock proteins, double stranded DNA, and components of extracellular matrix. Tumor microenvironments are rich in such molecules that can potentially trigger anti-tumor immune responses. Our group is interested in investigating potential TGF-b mediated mechanisms which help tumor cells to circumvent TLR-mediated anti-tumor responses and identify molecular targets that mediate these mechanisms for prevention and treatment of lung cancer.