In the setting of underlying immune suppression, Epstein Barr Virus (EBV) is a well-recognized oncogenic agent that induces the malignant proliferation of B-cells. EBV-lymphoproliferative disorders (LPDs) have recently been linked to immunosenescence. We present a unique case of Age-Related EBV-Lymphoproliferative Disorder (AR-EBVLPD) in a 70 year old female that deviates from the characteristic progression of this disease. Over the course of 18 months, the patient’s clinical condition worsened without a definitive diagnosis to explain the severe, atypical widespread chronic inflammation spanning her gastrointestinal tract, from esophagus to small bowel. The diagnosis of AR-EBVLPD, polymorphic extranodal subtype, was delayed until the patient developed a synchronous peripheral T-cell lymphoma. At this time, the patient was very sick, with a jejeunostomy tube. To our knowledge, this is the first time that a T-cell lymphoma has arisen in the context of a diagnosis with AR-EBVLPD. This rare, EBV induced malignant transformation of T-cells may explain the patient’s rapid clinical deterioration.
Recommended CitationChodoff, MSII, Alaina; Uppal, MD, Guldeep; and Gong, MD, Jerald Z., "Peripheral T-cell Lymphoma arising from Age-Related EBV-associated Lymphoproliferative Disorder (AR-EBVLPD)" (2014). Pathology Honors Program Student Research Symposium. Poster 23.