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<title>Department of Psychiatry and Human Behavior Faculty Papers</title>
<copyright>Copyright (c) 2013 Thomas Jefferson University All rights reserved.</copyright>
<link>http://jdc.jefferson.edu/phbfp</link>
<description>Recent documents in Department of Psychiatry and Human Behavior Faculty Papers</description>
<language>en-us</language>
<lastBuildDate>Wed, 27 Mar 2013 01:47:34 PDT</lastBuildDate>
<ttl>3600</ttl>


	
		
	







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<title>Sociocultural Influences on Diabetes Self-Management Behaviors in Older African Americans</title>
<link>http://jdc.jefferson.edu/phbfp/15</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/15</guid>
<pubDate>Mon, 25 Mar 2013 06:59:52 PDT</pubDate>
<description>
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	<p><strong>Objective.</strong> The purpose of this observational study was to describe the associations between cultural beliefs that are prevalent in older African Americans and adherence to diabetes self-management (DSM) behaviors.</p>
<p><strong>Methods.</strong> In a community population of 110 older African Americans with type 2 diabetes, the investigators administered surveys that assess present time orientation (PTO), future time orientation (FTO), and religiosity, as well as exercising habits, reading food labels, and checking blood glucose.</p>
<p><strong>Results.</strong> Participants who reported regularly exercising had significantly lower PTO scores and higher FTO and religiosity scores than participants who did not regularly exercise. Similarly, participants who reported reading food labels had lower PTO scores and higher FTO scores but did not differ in religiosity. Participants who reported checking blood glucose levels tended to have higher FTO scores but did not differ in PTO or religiosity. Participants who engaged in all three diabetes self-management behaviors had significantly lower PTO scores and higher FTO and religiosity scores.</p>
<p><strong>Conclusion.</strong> These data indicate that cultural diversity within older African Americans may influence DSM behaviors and contribute to disparities in diabetes outcomes in this high-risk population. Efforts to prevent complications of diabetes might benefit from consideration of these cultural factors.</p>

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<author>Barry W. Rovner et al.</author>


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<title>The Fear Factor in Takotsubo Cardiomyopathy: A Retrospective Cohort Study</title>
<link>http://jdc.jefferson.edu/phbfp/14</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/14</guid>
<pubDate>Wed, 09 Jan 2013 12:28:18 PST</pubDate>
<description>
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	<p><strong>Presented at: <a href="http://www.apm.org/ann-mtg/2012/index.shtml" target="_blank">Academy of Psychosomatic Medicine</a> in Atlanta Georgia.</strong></p>
<p><strong>BACKGROUND</strong><strong> </strong></p>
<p>•Takotsubo cardiomyopathy (TCM) is a transient, reversible acute cardiac syndrome that mimics acute MI</p>
<p>•Reportedly frequently precipitated by an emotionally stressful event</p>
<p>•Excessive catecholamine release is a possible pathophysiologic mechanism<sup>1</sup></p>
<p>•Prevalence of anxiety and mood disorders in TCM patients varies among studies, ranging from 21-40%<sup>2,3</sup></p>

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<author>Lex Denysenko, MD et al.</author>


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<title>Takotsubo Cardiomyopathy and Catatonia:  An Acute Stress Connection?</title>
<link>http://jdc.jefferson.edu/phbfp/13</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/13</guid>
<pubDate>Wed, 09 Jan 2013 12:23:36 PST</pubDate>
<description>
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	<p><strong>BACKGROUND</strong><strong> </strong></p>
<p>•Takotsubo cardiomyopathy (TCM):</p>
<p>•transient left ventricular dysfunction</p>
<p>•ECG changes and symptoms mimicking acute MI</p>
<p>•often precipitated by emotional stressor</p>
<p>•Catatonia is a psychomotor syndrome most commonly seen in mood disorders</p>
<p>•This is the first known reported case of TCM co-occurring with catatonia in the setting of acute psychological trauma and bereavement</p>

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<author>Lex Denysenko, MD et al.</author>


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<title>Universal or indicated screening in primary care?</title>
<link>http://jdc.jefferson.edu/phbfp/12</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/12</guid>
<pubDate>Wed, 11 May 2011 12:07:39 PDT</pubDate>
<description>
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	<p>To the Editor: In the November 2010 issue, Schmitt and colleagues (1) reported that the duration of visits increased when depression screening was conducted in primary care. This report is timely given recent recommendations for both adult and pediatric screening for depression in primary care. Schmitt and colleagues examined data representative of more than 641 million primary care visits in2005–2007 and found that when depression screening was documented in patients’ records, physicians’ time with patients increased significantly.</p>

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<author>Matthew Wintersteen, MD</author>


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<title>Improving function in Age-Related Macular Degeneration: design and methods of a randomized clinical trial.</title>
<link>http://jdc.jefferson.edu/phbfp/11</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/11</guid>
<pubDate>Mon, 28 Mar 2011 12:19:24 PDT</pubDate>
<description>
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	<p>Age-Related Macular Degeneration (AMD) is the leading cause of severe vision loss in older adults and impairs the ability to read, drive, and live independently and increases the risk for depression, falls, and earlier mortality. Although new medical treatments have improved AMD's prognosis, vision-related disability remains a major public health problem. Improving Function in AMD (IF-AMD) is a two-group randomized, parallel design, controlled clinical trial that compares the efficacy of Problem-Solving Therapy (PST) with Supportive Therapy (ST) (an attention control treatment) to improve vision function in 240 patients with AMD. PST and ST therapists deliver 6 one-hour respective treatment sessions to subjects in their homes over 2 months. Outcomes are assessed masked to treatment assignment at 3 months (main trial endpoint) and 6 months (maintenance effects). The primary outcome is targeted vision function (TVF), which refers to specific vision-dependent functional goals that subjects highly value but find difficult to achieve. TVF is an innovative outcome measure in that it is targeted and tailored to individual subjects yet is measured in a standardized way. This paper describes the research methods, theoretical and clinical aspects of the study treatments, and the measures used to evaluate functional and psychiatric outcomes in this population.</p>

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<author>Barry W Rovner et al.</author>


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<title>Feasibility and Impact of an Internet-based Adolescent Psychiatric Assessment Administered by Clinical Staff in the Pediatric Emergency Department</title>
<link>http://jdc.jefferson.edu/phbfp/10</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/10</guid>
<pubDate>Tue, 22 Mar 2011 13:45:58 PDT</pubDate>
<description>
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	<p><strong>Objective:</strong> Determine the adoption rate of the web-based Behavioral Health Screening- Emergency Department (BHS-ED) system into routine clinical practice in a pediatric emergency department (ED), and assess its impact on identification and assessment of psychiatric problems.</p>
<p><strong>Design:</strong> Descriptive design to evaluate feasibility of a clinical innovation.</p>
<p><strong>Setting:</strong> ED of an urban tertiary care children’s hospital.</p>
<p><strong>Participants:</strong> Non-acute, non-critical 14-18 year olds presenting with non-psychiatric complaints.</p>
<p><strong>Intervention:</strong> ED clinical staff initiated the BHS-ED which assesses depression, suicide, post-traumatic stress, substance use, and violence exposure.  Treating clinicians reviewed results and followed routine care practices thereafter.</p>
<p><strong>Outcome Measures</strong><strong>:</strong> Adoption rate of the BHS-ED by nursing staff, identification rates of occult psychiatric problems, and social worker or psychiatrist assessment.  Data were collected for 19 months before and 9 months during implementation.</p>
<p><strong>Results:</strong> Of 3979 eligible patients, 1327 (33%) were approached by clinical staff to complete the BHS-ED; of these, 857 (64.6%) completed the BHS-ED, and 470 (35.4%) refused.  During implementation, identification of adolescents with psychiatric problems significantly increased (4.2% vs. 2.5%, OR=1.70, 95% CI 1.38, 2.10) as did ED assessments by a social worker or psychiatrist (2.5% vs. 1.7%, OR 1.47, 95% CI 1.13, 1.90).  Of the 857 subjects who completed the BHS-ED, 10.5% were identified (OR=4.58, 95% CI 3.53, 5.94) and 8.3% were assessed (OR 5.12, 95% CI 3.80, 6.88).</p>
<p><strong>Conclusions:</strong> In a busy pediatric ED, computerized, self-administered adolescent behavioral health screening can be incorporated into routine clinical practice and can lead to small but significant increases in the identification of unrecognized psychiatric problems.</p>

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<author>Joel A. Fein, M.D. M.P.H et al.</author>


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<title>Off-label psychopharmacologic prescribing for children: history supports close clinical monitoring.</title>
<link>http://jdc.jefferson.edu/phbfp/9</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/9</guid>
<pubDate>Tue, 17 Aug 2010 13:22:55 PDT</pubDate>
<description>
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	<p>The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring.</p>

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<author>Julie M Zito et al.</author>


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<title>Attachment-based family therapy for adolescents with suicidal ideation: a randomized controlled trial.</title>
<link>http://jdc.jefferson.edu/phbfp/8</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/8</guid>
<pubDate>Wed, 05 May 2010 11:52:43 PDT</pubDate>
<description>
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	<p>OBJECTIVE: To evaluate whether Attachment-Based Family Therapy (ABFT) is more effective than Enhanced Usual Care (EUC) for reducing suicidal ideation and depressive symptoms in adolescents.   METHOD: This was a randomized controlled trial of suicidal adolescents between the ages of 12 and 17, identified in primary care and emergency departments. Of 341 adolescents screened, 66 (70% African American) entered the study for 3 months of treatment. Assessment occurred at baseline, 6 weeks, 12 weeks, and 24 weeks. ABFT consisted of individual and family meetings, and EUC consisted of a facilitated referral to other providers. All participants received weekly monitoring and access to a 24-hour crisis phone. Trajectory of change and clinical recovery were measured for suicidal ideation and depressive symptoms.   RESULTS: Using intent to treat, patients in ABFT demonstrated significantly greater rates of change on self-reported suicidal ideation at post-treatment evaluation, and benefits were maintained at follow-up, with a strong overall effect size (ES = 0.97). Between-group differences were similar on clinician ratings. Significantly more patients in ABFT met criteria for clinical recovery on suicidal ideation post-treatment (87%; 95% confidence interval [CI] = 74.6-99.6) than patients in EUC (51.7%; 95% CI = 32.4-54.32). Benefits were maintained at follow-up (ABFT, 70%; 95% CI = 52.6-87.4; EUC 34.6%; 95% CI = 15.6-54.2; odds ratio = 4.41). Patterns of depressive symptoms over time were similar, as were results for a subsample of adolescents with diagnosed depression. Retention in ABFT was higher than in EUC (mean = 9.7 versus 2.9).   CONCLUSIONS: ABFT is more efficacious than EUC in reducing suicidal ideation and depressive symptoms in adolescents. Additional research is warranted to confirm treatment efficacy and to test the proposed mechanism of change (the Family Safety Net Study).Clinical Trial Registry Information: Preventing Youth Suicide in Primary Care: A Family Model, URL: http://www.clinicaltrials.gov, unique identifier: NCT00604097.</p>

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<author>Guy S. Diamond et al.</author>


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<title>The doctor-patient relationship revisited. An analysis of the placebo effect.</title>
<link>http://jdc.jefferson.edu/phbfp/6</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/6</guid>
<pubDate>Fri, 06 Nov 2009 12:58:53 PST</pubDate>
<description>
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	<p>An overview of prescientific medicine, evolution, and individual human development is presented in an attempt to discover the generic factors operating in all interpersonal therapies. We hypothesize that the placebo effect rests on the universal human need for a group and, by symbolic extension, a system.</p>

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<author>Herbert M. Adler, MD et al.</author>


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<title>Activity loss is associated with cognitive decline in age-related macular degeneration.</title>
<link>http://jdc.jefferson.edu/phbfp/5</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/5</guid>
<pubDate>Mon, 23 Mar 2009 11:11:42 PDT</pubDate>
<description>
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	<p>BACKGROUND/METHODS: The objective of this study was to determine whether relinquishing cognitive, physical, and social activities is associated with an increased risk of cognitive decline in patients with age-related macular degeneration (AMD). We conducted a 3-year longitudinal study of 206 nondemented patients with AMD.</p>
<p>RESULTS: Twenty-three subjects (14.4%) declined cognitively. Age, sex, education, decline in visual acuity, and number of dropped activities were associated with cognitive decline; each additional dropped activity increased the risk by 58%. Subjects who relinquished three activities were 3.87 times (95% confidence interval, 1.95-7.76) more likely to become demented than subjects who relinquished no activities; those who relinquished five activities were 9.54 times (95% confidence interval, 3.05-30.43) more likely. A multivariate model demonstrated that number of dropped activities was a powerful predictor of cognitive decline after controlling for relevant risk factors, particularly for subjects younger than 80 years of age.</p>
<p>CONCLUSIONS: Relinquishing valued activities is associated with an increased risk of cognitive decline in older patients with vision loss caused by AMD. These data suggest the importance of promoting optimal cognitive and physical health in patients with AMD and perhaps other chronic diseases.</p>

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<author>Barry W. Rovner et al.</author>


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<title>The sociophysiology of caring in the doctor-patient relationship</title>
<link>http://jdc.jefferson.edu/phbfp/4</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/4</guid>
<pubDate>Mon, 29 Sep 2008 13:53:58 PDT</pubDate>
<description>
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	<p>The emotional investment required to construct a caring doctor-patient relationship can be justified on humane grounds. Can it also be justified as a direct physiologic intervention? Two lines of evidence point in this direction. People in an empathic relationship exhibit a correlation of indicators of autonomic activity. This occurs between speakers and responsive listeners, members of a coherent group, and bonded pairs of higher social animals. Furthermore, the experience of feeling cared about in a relationship reduces the secretion of stress hormones and shifts the neuroendocrine system toward homeostasis. Because the social engagement of emotions is simultaneously the social engagement of the physiologic substrate of those emotions, the process has been labeled sociophysiology. This process can influence the health of both parties in the doctor-patient relationship, and may be relevant to third parties.</p>

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<author>Herbert M. Adler</author>


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<title>Might a psychosocial approach improve our understanding of itching and scratching?</title>
<link>http://jdc.jefferson.edu/phbfp/3</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/3</guid>
<pubDate>Mon, 29 Sep 2008 13:53:57 PDT</pubDate>
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<author>Herbert M. Adler</author>


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<title>Normal sleep and circadian rhythms: Neurobiologic mechanisms underlying sleep and wakefulness</title>
<link>http://jdc.jefferson.edu/phbfp/2</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/2</guid>
<pubDate>Mon, 30 Jul 2007 08:56:59 PDT</pubDate>
<description>
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	<p>Sleep is a vital, highly organized process regulated by complex systems of neuronal networks and neurotransmitters. Sleep plays an important role in the regulation of central nervous system and body physiologic functions. Sleep architecture changes with age and is easily susceptible to external and internal disruption. Reduction or disruption of sleep can affect numerous functions varying from thermoregulation to learning and memory during the waking state.</p>

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<author>Dimitri Markov et al.</author>


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<title>Preface to the Psychiatric Clinics of North American, 2006</title>
<link>http://jdc.jefferson.edu/phbfp/1</link>
<guid isPermaLink="true">http://jdc.jefferson.edu/phbfp/1</guid>
<pubDate>Wed, 16 May 2007 13:44:39 PDT</pubDate>
<description>
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	<p>Introducton to the special issue on the sleep-psychiatry interface.</p>

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<author>Karl Doghramji</author>


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