Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis. Blood-derived proteases such as thrombin may enter the brain during pathological conditions like trauma, stroke, and inflammation and further disrupts the permeability of the blood-brain barrier, via incompletely characterized mechanisms. We examined the underlying mechanisms evoked by thrombin in rat brain microvascular endothelial cells (RBMVEC). Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca
Recommended CitationBrailoiu, Eugen; Shipsky, Megan M.; Yan, Guang; Abood, Mary E.; and Brailoiu, G. Cristina, "Mechanisms of modulation of brain microvascular endothelial cells function by thrombin." (2017). Jefferson College of Pharmacy Faculty Papers. Paper 33.
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