Document Type

Article

Publication Date

2-15-2017

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Brain Research, Volume 1657, February 2017, Pages 167-175

The published version is available at https://doi.org/10.1016/j.brainres.2016.12.011 Copyright © Elsevier

Abstract

Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis. Blood-derived proteases such as thrombin may enter the brain during pathological conditions like trauma, stroke, and inflammation and further disrupts the permeability of the blood-brain barrier, via incompletely characterized mechanisms. We examined the underlying mechanisms evoked by thrombin in rat brain microvascular endothelial cells (RBMVEC). Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Language

English

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