Document Type

Article

Publication Date

10-1-2009

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Pulmonary Pharmacology and Therapeutics Volume 22, Issue 5, October 2009, Pages 353-359. The published version is available at DOI: 10.1016/j.pupt.2008.12.006. Copyright © Elsevier Inc.

Abstract

Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation in asthma. ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in chronic severe asthma, increases in ASM mass may also render the airway irreversibly obstructed. Although the mechanisms by which ASM secretes cytokines and chemokines are shared with those regulating immune cells, there exist unique ASM signaling pathways that may provide novel therapeutic targets. This review provides an overview of our current understanding of the proliferative as well as synthetic properties of ASM.