Document Type

Article

Publication Date

1-1-2013

Comments

This article has been peer reviewed. It was published in: PLoS One

Volume 8, Issue 5, May 2013, e64265.

The published version is available at DOI: 10.1371/journal.pone.0064265.. Copyright © PLoS One

Abstract

Semaphorin 4D (Sema4D/CD100) is a 150-kDa transmembrane glycoprotein expressed by platelets and T-cells. When these cells are activated, Sema4D is cleaved proteolytically, generating a biologically active 120-kDa fragment (soluble Sema4D) capable of targeting receptors on platelets, B-cells, endothelial cells and tumor cells. However, its plasma levels and significance in heart failure (HF) have not been reported. In this study, we established an ELISA and detected soluble Sema4D in human plasma. In healthy controls, plasma Sema4D levels were higher in men than women (5.15±3.30 ng/mL, n = 63, vs. 4.19±2.39 ng/mL, n = 63, P

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