Document Type
Article
Publication Date
1-1-2013
Abstract
Semaphorin 4D (Sema4D/CD100) is a 150-kDa transmembrane glycoprotein expressed by platelets and T-cells. When these cells are activated, Sema4D is cleaved proteolytically, generating a biologically active 120-kDa fragment (soluble Sema4D) capable of targeting receptors on platelets, B-cells, endothelial cells and tumor cells. However, its plasma levels and significance in heart failure (HF) have not been reported. In this study, we established an ELISA and detected soluble Sema4D in human plasma. In healthy controls, plasma Sema4D levels were higher in men than women (5.15±3.30 ng/mL, n = 63, vs. 4.19±2.39 ng/mL, n = 63, P
Recommended Citation
Lu, Qiongyu; Dong, Ningzheng; Wang, Qi; Yi, Wenxiu; Wang, Yuxin; Zhang, Shengjie; Gu, Haibo; Zhao, Xin; Tang, Xiaorong; Jin, Boquan; Wu, Qingyu; Brass, Lawrence F; and Zhu, Li, "Increased levels of plasma soluble Sema4D in patients with heart failure." (2013). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 47.
https://jdc.jefferson.edu/petfp/47
PubMed ID
23741311
Comments
This article has been peer reviewed. It was published in: PLoS One
Volume 8, Issue 5, May 2013, e64265.
The published version is available at DOI: 10.1371/journal.pone.0064265.. Copyright © PLoS One